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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vivo

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Administrative data

Endpoint:
in vivo mammalian germ cell study: cytogenicity / chromosome aberration
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Justification for type of information:
Publication with limited detail
However, the results are widely cited by international reviews on safety of xanthates

Data source

Reference
Reference Type:
publication
Title:
No information
Author:
Babayan E.A. et all,
Year:
1979
Bibliographic source:
Biologicheskii Zhurnal Armenii Vol 31 pp. 425-428;

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 475 (Mammalian Bone Marrow Chromosomal Aberration Test)
Deviations:
not specified
GLP compliance:
not specified
Type of assay:
unspecified

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium O-isobutyl dithiocarbonate
EC Number:
246-805-2
EC Name:
Sodium O-isobutyl dithiocarbonate
Cas Number:
25306-75-6
Molecular formula:
C5H10OS2.Na
IUPAC Name:
sodium [(2-methylpropoxy)methanethioyl]sulfanide

Test animals

Species:
rat
Sex:
not specified

Administration / exposure

Route of administration:
other: inhalation and oral
Duration of treatment / exposure:
For 1, 15, 45 or 75 days

Results and discussion

Test results
Sex:
not specified
Genotoxicity:
ambiguous
Toxicity:
no effects
Vehicle controls validity:
not specified
Negative controls validity:
not specified
Positive controls validity:
not specified
Remarks on result:
other: Only headline results provided in this study

Any other information on results incl. tables

10mg/kg dose or 13.64 mg/m3concentration increase the number of chromosomal disorders in bone marrow cells.

1.74 mg/m3concentration had no mutagenic effect.

Applicant's summary and conclusion

Conclusions:
Interpretation of results: ambiguous
Executive summary:

This was a non-standard study and although only limited details provided in the data summary, it shows that over prolonged periods of dosing, there was a dose-related effect.


It must be noted that oral dosing would have resulted in expoure to the hydrolysis products Carbon Disulphide and Alcohol.  Carbon disulphides has been shown to lead to chromosomal effects in exposed workers.