Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1998

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
not specified
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Test material form:
other: water solution

Test animals / tissue source

Species:
rabbit

Test system

Vehicle:
water
Amount / concentration applied:
0.1 ml/eye as water solution pH=10.1, containing 456,1g/dm3 of the substance
Duration of treatment / exposure:
introduced into the conjunctival sacs of the right eye
Observation period (in vivo):
Observation were made after 1h, 24, 48 hours and then after 7 days
Number of animals or in vitro replicates:
1 male
Details on study design:
introduced into the conjunctival sacs of the right eye

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: IIPO
Time point:
other: 7
Score:
110
Irritation parameter:
other: IIPO
Time point:
other: 1-48 h
Score:
77.7
Irritant / corrosive response data:
After 1h, ¾ of the cornea surface was clouded,in the iris was noted congestion. The conjunctiva was reddened, red beet color, oedema, and discharge on palpebra. After 24h and 48h the changes in eye became more intense, pupil was visible in lower part of the eye, details of iris was not visible, the pupil reacted slowly on light. After 7 days changes in the eye became more intense, ¾ of cornea was clouded, in lower part of the cornea details of iris was not visible. In the cojunctiva of the lower palpebra necrosis was noted.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information
Conclusions:
Sodium isobutyl xanthate should be consider as seriously injured substance of the rabbit eyes.