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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2000

Materials and methods

Objective of study:
metabolism
Test guideline
Guideline:
other: no data

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

The expired CS2in the exhaled air was monitored in the study of the metabolism of xanthates with humans and guinea pigs. After injection of 50 or 100mg/kg of sodium ethyl xanthate in guinea pigs up to 7% was expired as CS2during 8 hours. The rate of elimination was dose-related, however the total percentage recovered was independent of dose after administration of sodium or

potassium xanthate. Co injection of ethyl alcohol with sodium ethyl xanthate increased rate of CS2elimination and greater total recovery.

Study of CS2elimination in breath after oral intake in human volunteers of 150 and 250 mg of sodium ethyl xanthate showed a maximum rate 13-57 µm/m3/h between 1-2h, complete elimination by 6h

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no bioaccumulation potential based on study results
Executive summary:

The expired CS2in the exhaled air was monitored in the study of the metabolism of xanthates with humans and guinea pigs. After injection of 50 or 100mg/kg of sodium ethyl xanthate in guinea pigs up to 7% was expired as CS2during 8 hours. The rate of elimination was dose-related, however the total percentage recovered was independent of dose after administration of sodium or

potassium xanthate. Co injection of ethyl alcohol with sodium ethyl xanthate increased rate of CS2elimination and greater total recovery.

Study of CS2elimination in breath after oral intake in human volunteers of 150 and 250 mg of sodium ethyl xanthate showed a maximum rate 13-57 µm/m3/h between 1-2h, complete elimination by 6h