Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: incident
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
No information
Author:
Donoghue A.M
Year:
1998
Bibliographic source:
Occupational Medicine, Vol. 37, no. 7,p. 469-470

Materials and methods

Study type:
poisoning incident
Endpoint addressed:
acute toxicity: dermal

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Type of population:
occupational
Route of exposure:
dermal
Reason of exposure:
accidental
Details on exposure:
A 32 year old male during a xanthate solution preparing became cover in xanthate powder and water solution staining his skin green from the chest down. Twenty hours later ,he experienced abdominal pain, loss of appetite, nausea, vomiting, headache and fatigue, and had mild itchiness at the wrists only. His symptoms resolved within 4 days. Many of the reported symptoms are consistent with carbon disulfide toxicity. A metabolite of carbon disulfide was detected in his urine.

Results and discussion

Applicant's summary and conclusion

Executive summary:

A 32 year old male during a xanthate solution preparing became cover in xanthate powder and water solution staining his skin green from the chest down. Twenty hours later ,he experienced abdominal pain, loss of appetite, nausea, vomiting, headache and fatigue, and had mild itchiness at the wrists only. His symptoms resolved within 4 days. Many of the reported symptoms are consistent with carbon disulfide toxicity. A metabolite of carbon disulfide was detected in his urine.