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EC number: 639-566-4 | CAS number: 165184-98-5
A panel of 138 male and female human volunteers participated in a repeat insult patch test in which a 20% solution of alpha-hexylcinnamaldehyde in 3:1 ethanol:diethylphthalate (0.3ml) was placed onto Hill Top Chambers and applied to the back of the subjects. Saline and vehicle control patches were also used. During the induction phase nine patch applications were made and these were removed 24hrs after application. Following a rest period, a challenge patch was applied and the sites scored 24, 48, and 72hrs after application. One subject displayed mild erythema accompanied by moderate edema at both 48hr and 72hr readings to both the test article and vehicle patches. At 96hr reading it subsided to barely perceptible erythema accompanied by mild dryness. The subject was scheduled to participate in rechallenge but was lost to follow up and the results for this indiviual were considered inconclusive. It was concluded that under the conditions of this study the test substance did not show evidence of induced allergic contact dermatitis in 99% of the test population.
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