Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 639-566-4 | CAS number: 165184-98-5
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
In an OECD 202 study on Daphnia magna performed according to GLP, effects were observed after 24 and 48 h using a flow-through method with a solvent and although floaters were observed in all trest concentrations except the control this study is considered suitable for hazard assessment .
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.247 mg/L
Additional information
Two OECD 202 studies on Daphnia magna were performed according to GLP, one using a flow-through method with a solvent and one as a WSF method with all loadings above the limit of solubility, under semi-static conditions and in the dark. The first study using solvent was considered valid as, further to a recent solubility study using a slow-stir method in pure water and daphnid medium, the solubiltiy in water was observed to be much higher than previously thought, around 1.5 mg/L. The previous lower solubility results of 0.3 mg/L were found to be caused by loss of the test substance during centrifugation step.
In the second study which is considered a supporting study, no significant effect (5% immobilisation) was observed after 48 h in a "Water Soluble Fraction" (WSF) concentration of 1 mg/L which is greater than the water solubility limit of the test substance however, centrifugation was used prior to exposure and the substance recovery was found to be <0.0018 mg/L (LOQ) of hexyl cinnamic aldehyde. It is likely that the substance was lost to the centrifuge tubes (as has recently been observed in the solubility studies) therefore this study can only be used as a supporting study in the hazard assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
