Registration Dossier
Registration Dossier
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EC number: 241-527-8 | CAS number: 17527-29-6
Endpoint summary
Administrative data
Description of key information
OECD 231 (See Section 6.1.8. for study summary. No endpoint summary functionality is available in Section 6.1.8 for this endpoint, therefore the summary is provided here): At 107 mg test item/L (the top dose; day 21): a statistically significant increase compared to the control was observed in normalised hind limb length and developmental stage (advanced development observed).
At 1.07 mg test item/L, no statistically significant difference compared to the control was observed for any endpoint. At 10.7 mg test item/L, wet weight and snout vent length were statistically significantly increased compared to the control on day 7, whereas on day 21 no statistically significant difference compared to the control was observed for any endpoint. At 107 mg test item/L on day 7, no statistically significant difference regarding developmental stage was detected; however, statistically significant advanced development on day 21 was observed. Body wet weight and snout vent length were statistically significantly increased on day 7 of exposure, but not on day 21. Under the conditions of this study, there were no changes in the thyroid glands that could be attributed to treatment with the test item.
OECD 234: Please see Section 6.1.2 for the Endpoint Summary for the Fish Sexual Development Test.
Additional information
Endocrine disruptor testing in aquatic vertebrates - in vivo - Endpoint Summary - IUCLID Section 6.1.8 - OECD 231 (Amphibian Metamorphosis Assay)
Summary
A test in accordance with OECD 231 (2009) was performed on PFHxA in order to assess the thyroid activity potential of the test item. See Section 6.1.8 for the OECD 231 robust study summary.
Fertilised Xenopus laevis (African clawed frog) eggs were hatched and the tadpoles reared until they reached NF (Nieuwkoop & Faber, 1994) developmental stage 51. The organisms were then exposed in a flow-through test for 21 days. There were 4 treatment groups (3 concentrations of test item and 1 negative control), with 4 replicates each containing 20 organisms. The test concentrations used were 1.07, 10.7 and 107 mg test item/L and a control, corresponding to 1.0, 10 and 100 mg perfluorohexanoate/L. Analytical verification of the test item concentration in test medium was performed (the overall mean recovery value was 99 %).
The endpoints assessed in the study were developmental stage (day 7 and 21); body weight (day 7 and 21); snout to vent length (SVL; day 7 and 21); hind limb length (HLL; day 7 and 21) thyroid histology (day 21) as indicators of thyroidal activity of the test item. Furthermore, survival and behaviour were monitored daily.
Key results: At 107 mg test item/L, statistically significant advanced development on day 21 was observed compared to the control. A statistically significant increase of HLL (normalised by SVL) at 107 mg test item/L on day 7 and 21 were observed compared to the control.
At 1.07 mg test item/L, no statistically significant difference compared to the control was observed for any endpoint. At 10.7 mg test item/L, wet weight and snout vent length were statistically significantly increased compared to the control on day 7, whereas on day 21 no statistically significant difference compared to the control was observed for any endpoint. At 107 mg test item/L on day 7, no statistically significant difference regarding developmental stage was detected; however, statistically significant advanced development on day 21 was observed. Body wet weight and snout vent length were statistically significantly increased on day 7 of exposure, but not on day 21. Under the conditions of this study, there were no changes in the thyroid glands that could be attributed to treatment with the test item.
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