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EC number: 911-238-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Toxicity Summary
Acute oral toxicity:
In a recent study (2005), performed according to actual guidelines, an LD50 of >2000 mg/kg bw was determined. The test substance was administered in CMC/Tween 80). There were no adverse effects noted in the animals and no systemic effects were observed.
Acute dermal toxicity:
In a recent study, performed according to actual guidelines, the LD50 was >2000 mg/kg bw and no adverse effects were noted in the animals. No indication for a dermal absorption was obtained from this study.
Repeated dose toxicity:
Results of a 28-Day toxicity study and of a 90-Day toxicity study demonstrate an absorption of the test substance in the gastrointestinal tract and a distribution in the body. The test substance induced mild hepatic alterations, notable as hepatocellular vacuoles and by some clinical-chemical parameters. A decrease in the number of platelets in the blood and some organ weight changes were noted in addition.
All test substance related findings were present only in a low grade of severity and never became life-threatening.
The presence of hepatocellular vacuoles is attributed to the test substance, but, in the absence of clear signs of toxicity, they are interpreted rather as adaptive changes.
None of the test substance related effects persisted until the end of the recovery period. There was no pronounced sex difference in the response to the test substance.
The No-observed-adverse-effect-level (NOAEL) of "Resin 835 A" was at 316 mg per kg body weight and day in both sexes, based on possible adverse effects in the high dosed group. No severe toxic effects were noted even at a dose of 1000 mg/kg.
In a Prenatal Developmental Toxicity Study (gavage) 250 mg/kg bw/day was associated with decrease in food consumption and lower maternal body weights during the initial phase of treatment (Day 5 -8). At 1000 mg/kg bw/day there was a reduction in maternal body weights gains during the treatment period GD 5 to 20 (-15.7%) and in food consumption during the treatment period GD 5 to 20 (-17.3%) and throughout gestation period 0 to 20 (-13.4 %).
At 1000 mg/kg/day, the male and female fetal weights (-8.9% and -7.3%, respectively) were significantly lower and were considered to be treatment-related. Fetal skeletal examination revealed significant increase in minor anomalies such as Extra, Accessory and Rudimentary rib No.14 at 1000 mg/kg/day and this finding was attributed to maternal stress due to treatment as evidenced by decrease in maternal body weight / body weight gain, and food consumption.
Based on the above findings, it is concluded that, No Observed Adverse Effect Level (NOAEL) for Maternal toxicity and Fetal developmental toxicity is 250 mg/kg/day
Reproductive toxicity
In a Prenatal Developmental Toxicity Study (gavage) 250 mg/kg bw/day was associated with decrease in food consumption and lower maternal body weights during the initial phase of treatment (Day 5 -8). At 1000 mg/kg bw/day there was a reduction in maternal body weights gains during the treatment period GD 5 to 20 (-15.7%) and in food consumption during the treatment period GD 5 to 20 (-17.3%) and throughout gestation period 0 to 20 (-13.4 %).
At 1000 mg/kg/day, the male and female fetal weights (-8.9% and -7.3%, respectively) were significantly lower and were considered to be treatment-related. Fetal skeletal examination revealed significant increase in minor anomalies such as Extra, Accessory and Rudimentary rib No.14 at 1000 mg/kg/day and this finding was attributed to maternal stress due to treatment as evidenced by decrease in maternal body weight / body weight gain, and food consumption.
Genetic toxicity
The test item gave negative results in one bacterial gene mutation test, in one mammalian gene mutation test and in one mammalian cytogenetic study, regardless whether tested without or with the addition of metabolizing enzymes. All studies were performed under GLP and according to current guidelines. The test item was non-mutagenic in all three assays.
Toxicokinetic summary
Absorption / distribution
Absorption of the test substance in the gastrointestinal tract and a distribution in the body was demonstrated by two oral repeated dose toxicity studies and a prenatal developmental toxicity study with the test item. No systemic effects were noted after single oral administration (acute oral toxicity).
No systemic effects were noted after single dermal exposure to the test substance (acute dermal toxicity study). The high partition coefficient n-octanol/water (ca. 6.5) and the low water solubility (<1 mg/L) might however enable a penetration of the test item through biological membranes. A potential for bioaccumulation might also exist, based on the high partition coefficient.
Metabolism
No relevant differences occurred in the three mutagenicity studies with and without the addition of a metabolising system. Therefore no indication of the importance of the metabolism of the test item was obtained from these studies.
Excretion
No information is available on excretion of the test item.
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