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EC number: 237-222-4 | CAS number: 13701-59-2
Studies of acute oral, dermal and inhalation toxicity are available for the submission substance.
No further data
The test substance Busan 11-M1 was administered to 8 rats/sex/dose male and female Sprague-Dawley rats in dosages administered at 0.34, 0.50, 0.73, 1.07, 2.31, 5.0 g/kg. The test animals were observed for 14 days following administration. Under the conditions of this study, the oral LD50 of the test substance was determined to be 0.85 g/kg in males and 0.53 g/kg in females . Based on this result, Busan 11-M1 is classified as Category 4, signal word warning, hazard statement H302: Harmful if swallowed in accordance with Regulation EC No. 1272/2008.
In a study conducted by Coate (1983), the test substance, Busan 11-M1, was examined for its ability to cause toxicity when administered via whole-body inhalation to male and female Sprague-Dawley rats. The test animals were exposed to nominal concentrations of the test substance 14.52 mg/L and 21.70 mg/L. The test animals were exposed to the test substance via whole-body inhalation for a period of up to 4 hours. They were then observed for 14 days following treatment to determine the effects. Under the conditions of this study, there were no test substance related mortalities observed and no test substance related adverse effects recorded. The LC50 is greater than >3.54mg/L air (analytical) the maximum attainable concentration. Based on this result, the test substance does not require classification for acute inhalation toxicity according to Regulation EC No. 1272/2008.
In a study conducted by Thompson (1979) the test substance, Busan 11-M1, was tested for its ability to cause acute dermal toxicity when applied to male and female New Zealand White albino rabbits. The exposure site on each test animal was shaved and abraded prior to application of the test material and the test substance moistened with physiological saline was applied. A rubber sleeve wrap was applied to the test site and remained in place for the 24 hours exposure period. During this exposure period, the test animals were immobilised. Following exposure, the test animals were placed in cages for the 14 day observation period. Under the conditions of this study, the dermal LD50 of Busan 11-M1, was determined to be >2.0 g/kg bw, equivalent to 2000 mg/kg bw. Based on this result, the test substance does not warrant classification for acute dermal toxicity in accordance with Regulation EC No. 1272/2008.
The acute oral LD5 was found to be 530 mg/kg bw; the acute inhalation LC50 was found to be >3540 mg/m3; the acute dermal LD50 was found to be >2000 mg/kg bw. The substance is therefore shown to be of low acute toxicity by all routes investigated.
The oral LD50 was found to be 850 mg/kg bw in males and 530 mg/kg in females. Therefore it is classified as Category 4, signal word warning, hazard statement H302: Harmful if swallowed.
The results of the acute dermal and inhalation toxicity studies performed with the substance do not trigger classification according to the CLP Regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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