2-aminoethanol

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1966

Report date:

1966

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2-aminoethanol

EC Number:

205-483-3

EC Name:

2-aminoethanol

Cas Number:

141-43-5

Molecular formula:

C2H7NO

IUPAC Name:

2-aminoethanol

Test material form:

liquid

Test animals

Species:

rabbit

Strain:

Vienna White

Test system

Type of coverage:

occlusive

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Controls:

no

Duration of treatment / exposure:

1, 5, 15 min, 20 hrs

Observation period:

8 days

Number of animals:

2

Details on study design:

TEST SITE
- Area of exposure: 2.5 x 2.5 cm

REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 1, 5 and 15 min, respectively

SCORING SYSTEM: The original scoring system was converted into Draize scores

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Remarks:

1 min exposure

Basis:

mean

Time point:

24/48/72 h

Score:

1.5

Max. score:

4

Reversibility:

fully reversible within: 8 days

Results 2

Irritation parameter:

edema score

Remarks:

1 min exposure

Basis:

mean

Time point:

24/48/72 h

Score:

0

Max. score:

4

Results 3

Irritation parameter:

erythema score

Remarks:

5 min exposure

Basis:

mean

Time point:

24/48/72 h

Score:

1.5

Max. score:

4

Reversibility:

fully reversible within: 8 days

Results 4

Irritation parameter:

edema score

Remarks:

5 min exposure

Basis:

mean

Time point:

24/48/72 h

Score:

0.16

Max. score:

4

Reversibility:

fully reversible within: 48 h

Results 5

Irritation parameter:

erythema score

Remarks:

15 min exposure

Basis:

mean

Time point:

24/48/72 h

Score:

1.83

Max. score:

4

Reversibility:

fully reversible within: 8 days

Results 6

Irritation parameter:

edema score

Remarks:

15 min exposure

Basis:

mean

Time point:

24/48/72 h

Score:

0.66

Max. score:

4

Reversibility:

fully reversible within: 8 days

Results 7

Irritation parameter:

erythema score

Remarks:

20 hr exposure

Basis:

mean

Time point:

24/48/72 h

Score:

3

Max. score:

4

Reversibility:

not reversible

Results 8

Irritation parameter:

edema score

Remarks:

20 hr exposure

Basis:

mean

Time point:

24/48/72 h

Score:

1.33

Max. score:

4

Reversibility:

not fully reversible within: 8 days

Other effects:

bleedings and necrosis of the skin

Any other information on results incl. tables

 

Readings	Animal	Exposure period: 1 min
		Erythema	Edema	Additional findings
1 min	1	2	0	spotted appearance
	2	0	0
24 h	1	2	0	spotted appearance
	2	1	0
48 h	1	2	0	spotted appearance
	2	1	0
72 h	1	2	0	spotted appearance
	2	0	0
8 d	1	0	0	slight desquamation
	2	0	0
Mean 24, 48, 72 h	1	2	0
	2	0.66	0
Mean 24, 48, 72 h	1-2	1.33	0

 

Readings	Animal	Exposure period: 5 min
		Erythema	Edema	Additional findings
5 min	1	2	0	pea-sized spotted erythema, bleedings
	2	3	0	bleedings
24 h	1	2	0	spotted appearance
	2	2	2	grey-brown appearance
48 h	1	2	0	spotted appearance
	2	0	0	leather-like necrosis
72 h	1	2	0	spotted appearance
	2	0	0	brown-red leather-like necrosis, partly anaemic
8 d	1	0	0	pea-sized crusts, desquamation
	2	0	0	brown-red leather-like necrosis, partly anaemic
Mean 24, 48, 72 h	1	2	0
	2	1	0.33
Mean 24, 48, 72 h	1-2	1.5	0.16

 

Readings	Animal	Exposure period: 15 min
		Erythema	Edema	Additional findings
15 min	1	2	0	bleedings
	2	3	0	bleedings
24 h	1	2	2	pea-sized brown erythema
	2	2	0	grey-brown spotted appearance, bleedings
48 h	1	2	2	pea-sized brown erythema
	2	0	0	leather-like anaemic necrosis exceeding area of exposure
72 h	1	3	0	pea-sized crusts, spotted appearance
	2	0	0	brown-red leather-like necrosis, partly anaemic
8 d	1	0	0	pea-sized crusts, desquamation
	2	0	0	brown-red leather-like necrosis, partly anaemic
Mean 24, 48, 72 h	1	2	1.33
	2	1.66	0
Mean 24, 48, 72 h	1-2	1.83	0.66

 

Readings	Animal	Exposure period: 20 hours
		Erythema	Edema	Additional findings
24 h	1	3	2	grey-brown, exceeding area of exposure
	2	3	2	grey-brown anaemic necrosis,
48 h	1	3	2	grey-brown, exceeding area of exposure
	2	3	0	black brown hard necrosis
72 h	1	3	2	black-brown slideable necrosis
	2	3	0	black brown hard necrosis
8 d	1	3	2	black-brown slideable necrosis
	2	3	0	black brown hard necrosis
Mean 24, 48, 72 h	1	3	2
	2	3	0.66
Mean 24, 48, 72 h	1-2	3	1.33

Applicant's summary and conclusion

Interpretation of results:

Category 1 (corrosive) based on GHS criteria