Registration Dossier
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EC number: 211-463-5 | CAS number: 646-06-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
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- Density
- Particle size distribution (Granulometry)
- Vapour pressure
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- Endpoint summary
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- Environmental data
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
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- Toxicological Summary
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- Acute Toxicity
- Irritation / corrosion
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- Genetic toxicity
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- Additional toxicological data

Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Two studies according to OECD 203 and/or EC C.1 guidelines and according to GLP principles have been performed under static or semi static conditions. The static study showed a loss by measured concentration of more than 20% and therefore does not fulfill the ciriteria for validity of the test and was therefore disregarded. No death occured during the study. In the second semi static study the measured concentration was stable and can be considered of appropriate quality. In this study also no death occured. The highest concentration can serve as a realistic observed worst-case NOEC. The results OECD Guideline 203 test shows low toxicity. The determined LC50 value of > 100 mg/L does not result in classification for aquatic toxicity.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 95.4 mg/L
Additional information
One study according to OECD 203 and/or EC C.1 guidelines and according to GLP principles has been performed under static conditions. Measured concentrations (110 mg a.s./L on day 0 and 11.7 mg a.s./L on day 4 showed a loss greater than 20% and therefore the study does not fulfill the criteria for validity of the test. and is disregarded. No death occurred during the study. OECD calculation based on mean measured concentrations (96-h LC50 >60.9 mg/L) should not used for risk assessment as better data from the semi-static test are available.
The results from a semi static study according to OECD 203 and/or EC C.1 guidelines and according to GLP principles showed stable concentration during the test duration of 96 h. At the highest measured concentration 95.4 mg a.s./L no death occurred. As this study was a limit test no final conclusions should be drawn from the results.
Based on absence of death in both studies 1,3 -Dioxolan has an 96-hour LC0 of >95.4 mg a.s./L.
For further evaluation of the aquatic toxicity to fish a QSAR evaluation with the ECOSAR (v1.00) was performed.
ECOSAR Program (v1.00) Results:
==============================
SMILES : O(CCO1)C1
CHEM : 1,3-Dioxolane
CAS Num:
ChemID1:
ChemID2:
ChemID3:
MOL FOR: C3 H6 O2
MOL WT : 74.08
Log Kow: -0.31 (KowWin estimate)
Melt Pt:
Wat Sol: 1E+006 mg/L (experimental database)
ECOSAR v1.00 Class(es) Found
------------------------------
Neutral Organics
Predicted
ECOSAR Class Organism Duration End Pt mg/L (ppm)
=========================== ================== ======== ====== ==========
Neutral Organics : Fish 96-hr LC50 6120.612
Neutral Organics : Fish 14-day LC50 5962.711
Neutral Organics : Fish 30-day ChV 546.327
Neutral Organics : Fish (SW) 96-hr LC50 10139.949
Neutral Organics : Fish (SW) ChV 236.697
Note: * = asterisk designates: Chemical may not be soluble
enough to measure this predicted effect.
Neutral Organics:
----------------
For Fish LC50 (96-h), Daphnid LC50, Mysid: If the log Kow is greater
than 5.0, or if the compound is solid and the LC50 exceeds the water
solubility by 10X, no effects at saturation are predicted.
For Fish LC50 (14-day) and Earthworm LC50: If the log Kow is greater
than 6.0, or if the compound is solid and the LC50 exceeds the water
solubility by 10X, no effects at saturation are predicted.
For Green Algae Acute Toxicity Values: If the log Kow of the chemical is
greater than 6.4, or if the compound is solid and the EC50 exceeds the water
solubility by 10X, no effects at saturation are predicted for these endpoints.
For All Chronic Toxicity Values: If the log Kow of the chemical is greater
than 8.0, or if the compound is solid and the ChV exceeds the water solubility
by 10X, no effects at saturation are predicted for these endpoints.
ECOSAR v1.00 SAR Limitations:
----------------------------
Maximum LogKow: 5.0 (Fish 96-hr LC50; Daphnid LC50, Mysid LC50)
Maximum LogKow: 6.0 (Fish 14-day LC50; Earthworm LC50)
Maximum LogKow: 6.4 (Green Algae EC50)
Maximum LogKow: 8.0 (ChV)
Maximum Mol Wt: 1000
From the available studies, because one study failed and the other is based on a limit test no fixed value for the LC50 can be derived. In any case the results will not qualify for classification and labeling.
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