1,3-dioxolane

Short-term toxicity to fish

Description of key information

A study according to OECD 203 and EC C.1 guidelines and according to GLP principles has been performed under semi static conditions. During this study, the measured concentration was stable and can be considered of appropriate quality and no death occured. The highest concentration can serve as a realistic observed worst-case NOEC. The results of the OECD Guideline 203 test shows low toxicity. The determined LC50 value of > 95.4 mg/L does not result in classification for aquatic toxicity.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Dose descriptor:

LC50

Effect concentration:

> 95.4 mg/L

Additional information

The results from a semi static study according to OECD 203 and EC C.1 guidelines and according to GLP principles showed stable concentration during the test duration of 96 h. At the highest measured concentration of 95.4 mg/L no death occurred. As this study was a limit test no final conclusions should be drawn from the results.

 

Based on absence of death in both studies, 1,3-Dioxolane has an 96-hour LC0 of >95.4 mg/L.

 

For further evaluation of the aquatic toxicity to fish a QSAR evaluation with the ECOSAR (v1.00) was performed.

 

ECOSAR Program (v1.00) Results:

==============================

SMILES : O(CCO1)C1

CHEM  : 1,3-Dioxolane

CAS Num:

ChemID1:

ChemID2:

ChemID3:

MOL FOR: C3 H6 O2

MOL WT : 74.08

Log Kow: -0.31 (KowWin estimate)

Melt Pt:

Wat Sol: 1E+006 mg/L (experimental database)

 

ECOSAR v1.00 Class(es) Found

------------------------------

Neutral Organics

Predicted

ECOSAR Class                Organism           Duration End Pt  mg/L (ppm)

=========================== ================== ======== ======  ==========

Neutral Organics          : Fish               96-hr    LC50    6120.612

Neutral Organics          : Fish               14-day   LC50    5962.711

Neutral Organics          : Fish               30-day   ChV      546.327

Neutral Organics          : Fish (SW)         96-hr    LC50   10139.949

Neutral Organics          : Fish (SW)                   ChV      236.697

 

Note: * = asterisk designates: Chemical may not be soluble

enough to measure this predicted effect.

 

Neutral Organics:

----------------

For Fish LC50 (96-h), Daphnid LC50, Mysid: If the log Kow is greater

than 5.0, or if the compound is solid and the LC50 exceeds the water

solubility by 10X, no effects at saturation are predicted.

 

For Fish LC50 (14-day) and Earthworm LC50: If the log Kow is greater

than 6.0, or if the compound is solid and the LC50 exceeds the water

solubility by 10X, no effects at saturation are predicted.

 

For Green Algae Acute Toxicity Values: If the log Kow of the chemical is

greater than 6.4, or if the compound is solid and the EC50 exceeds the water

solubility by 10X, no effects at saturation are predicted for these endpoints.

 

For All Chronic Toxicity Values: If the log Kow of the chemical is greater

than 8.0, or if the compound is solid and the ChV exceeds the water solubility

by 10X, no effects at saturation are predicted for these endpoints.

 

ECOSAR v1.00 SAR Limitations:

----------------------------

Maximum LogKow: 5.0 (Fish 96-hr LC50; Daphnid LC50, Mysid LC50)

Maximum LogKow: 6.0 (Fish 14-day LC50; Earthworm LC50)

Maximum LogKow: 6.4 (Green Algae EC50)

Maximum LogKow: 8.0 (ChV)

Maximum Mol Wt: 1000

 

Because the study performed is based on a limit test no fixed value for the LC50 can be derived. In any case the results will not qualify for classification and labeling.