Registration Dossier
Registration Dossier
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EC number: 201-202-3 | CAS number: 79-39-0
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Beitrag zur Wirkung der Alkylmonomere auf die Haut.
- Author:
- Mikulecky Z, Kolisch P, Znojemsky S
- Year:
- 1 960
- Bibliographic source:
- Symposium Dermatologorum Corpus Lectionum 1st: 238-241, Prag 1960, ed. Konopik J.|(Pub. 1962)
Materials and methods
- Study type:
- case report
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methacrylamide
- EC Number:
- 201-202-3
- EC Name:
- Methacrylamide
- Cas Number:
- 79-39-0
- Molecular formula:
- C4H7NO
- IUPAC Name:
- methacrylamide
Constituent 1
Method
- Route of administration:
- dermal
Results and discussion
- Results of examinations:
- RESULT OF CASE REPORT:
5 patients who were in contact with 1 % methacrylamide (solvent not indicated). They were previously exposed to acrylamide and other acrylates or
methacrylates. 2 out of the 5 patients showed a positive reaction after 72 hours. There were also positive reactions with acrylates. The authors don't distinguish between a irritative- and sensitzing reaction. 30 volunteers (control group) with normal skin reactions showed no positive reactions
when tested with 1 %- or 5 % methacrylamide.
Applicant's summary and conclusion
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