Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
Beitrag zur Wirkung der Alkylmonomere auf die Haut.
Author:
Mikulecky Z, Kolisch P, Znojemsky S
Year:
1960
Bibliographic source:
Symposium Dermatologorum Corpus Lectionum 1st: 238-241, Prag 1960, ed. Konopik J.|(Pub. 1962)

Materials and methods

Study type:
case report
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Methacrylamide
EC Number:
201-202-3
EC Name:
Methacrylamide
Cas Number:
79-39-0
Molecular formula:
C4H7NO
IUPAC Name:
methacrylamide

Method

Route of administration:
dermal

Results and discussion

Results of examinations:
RESULT OF CASE REPORT:

5 patients who were in contact with 1 % methacrylamide (solvent not indicated). They were previously exposed to acrylamide and other acrylates or
methacrylates. 2 out of the 5 patients showed a positive reaction after 72 hours. There were also positive reactions with acrylates. The authors don't distinguish between a irritative- and sensitzing reaction. 30 volunteers (control group) with normal skin reactions showed no positive reactions
when tested with 1 %- or 5 % methacrylamide.

Applicant's summary and conclusion