Registration Dossier
Registration Dossier
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EC number: 618-939-5 | CAS number: 933999-84-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
In the guinea pig Optimization test 1,6-Hexanediol Diglycidylether (HDDGE) at a concentration for challenge of 1% wt/v elicited positive dermal reactions in all 20 animals. In the mouse LLNA asay HDDGE had an Estimated Concentration 3 of 1.9% based on DPMs suggesting that HDDGE is a moderate dermal sensitizer. Based on the results of the mouse LLNA study and applying E.C.H.A. guidance (RIP Chapter 8) the Worker dermal DMEL/DNEL is estimated to be 22.6 ug/cm2.
Migrated from Short description of key information:
1,6-Hexanediol Diglycidylether (HDDGE) was accessed for dermal sensitizing potential in a guinea pig Optimization test and a O.E.C.D. Testing Guideline mouse LLNA assay conducted with GLP compliance. HDDGE gave a positive skin sensitizing response in both studies.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
No data
Justification for classification or non-classification
The positive findings from both the guinea pig Optimization test and the mouse LLNA study are sufficient to support the Classification and Labeling of 1,6 -Hexanediol Diglycidylether (HDDGE) as R43, "May cause sensitization by skin contact".
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