Registration Dossier

Diss Factsheets

Administrative data

Description of key information

1,6-Hexanediol Diglycidylether was assessed for eye and skin irritation potential in rabbits following methods established by Draize.  Skin irritation was measured following a 24 hr occluded treatment.  Eye irritation was scored in both washed and unwashed rabbit eyes with the observation carried out to study day 14.    

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

1,6-Hexanediol Diglycidylether (HDDGE) induced a mean erythema score from three rabbits of 2.0 at 24 hr and 2.5 at 72 hr following a 24 hr occlusive treatment. This severe treatment conditions is not recommended by the current O.E.C.D. Testing Guideline for Skin Irritation/Corrosion. Repeated 24 hr occluded dermal exposure was found to be corrosive to rabbit skin in two independent studies. Based on the conjunctival irritation scores from 2 of 3 animals, HDDGE is a rabbit eye irritant. However, washing of the treated eye with physiological saline within 30 seconds of instillation prevented the irritational response.

Effects on skin irritation/corrosion: irritating

Effects on eye irritation: irritating

Justification for classification or non-classification

Based on the findings from an outdated skin irritation study conducted on rabbits with the severe exposure conditions of a 24 hr occluded tretment, 1,6-Hexanediol Diglycidylether is a skin irritant. The results of a rabbit eye irritation study demonstrate that 1,6-Hexanediol Diglycidylether is also an eye irritant.