Registration Dossier
Registration Dossier
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EC number: 618-939-5 | CAS number: 933999-84-9
Endpoint summary
Administrative data
Description of key information
1,6-Hexanediol Diglycidylether was assessed for eye and skin irritation potential in rabbits following methods established by Draize. Skin irritation was measured following a 24 hr occluded treatment. Eye irritation was scored in both washed and unwashed rabbit eyes with the observation carried out to study day 14.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
1,6-Hexanediol Diglycidylether (HDDGE) induced a mean erythema score from three rabbits of 2.0 at 24 hr and 2.5 at 72 hr following a 24 hr occlusive treatment. This severe treatment conditions is not recommended by the current O.E.C.D. Testing Guideline for Skin Irritation/Corrosion. Repeated 24 hr occluded dermal exposure was found to be corrosive to rabbit skin in two independent studies. Based on the conjunctival irritation scores from 2 of 3 animals, HDDGE is a rabbit eye irritant. However, washing of the treated eye with physiological saline within 30 seconds of instillation prevented the irritational response.
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: irritating
Justification for classification or non-classification
Based on the findings from an outdated skin irritation study conducted on rabbits with the severe exposure conditions of a 24 hr occluded tretment, 1,6-Hexanediol Diglycidylether is a skin irritant. The results of a rabbit eye irritation study demonstrate that 1,6-Hexanediol Diglycidylether is also an eye irritant.
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