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EC number: 228-204-7 | CAS number: 6166-86-5
RESULTS AND DISCUSSION
Viability / Mortality / Macroscopic Findings There were no deaths during the course of the study and no necropsies were performed.
Clinical Signs No signs of systemic toxicity were observed in any of the animals.
Body Weights (See attached Summary Tables and Individual Tables) The body weight of the animals was within the range commonly recorded for animals of this strain and age.
Skin Reactions in the Induction (See Individual Tables on p. ) No skin effect (grade 0) was observed in the control group after treatment with acetone alone during the three weeks of induction. Discrete/patchy erythema (grade 1) was observed in all (100%) animals in the first and third induction weeks and in 12 out of 20 (60%) animals in the second induction week after treatment with the test item at 100%.
The purpose of this skin sensitizing study was to assess the ability of the test item 2,4,6,8,10-Pentamethylcyclopentasiloxane, to induce delayed contact hypersensitivity when applied topically to albino guinea pigs. A modified Buehler method (Ritz and Buehler, 1980) was used. The study was conducted according to OECD Guidelines for Testing of Chemicals, Number 406 "Skin Sensitization”.
Twenty male animals of the test group were treated topically with 2,4,6,8,10-Pentamethylcyclopentasiloxane at 100% (undiluted) once a week for a 3-week induction phase. Ten animals in the control group were treated in the same way as the test animals, but with the vehicle (acetone) only. Two weeks after the final induction application the control and test animals were challenged with the test item at 15% in acetone and acetone alone.
There was no skin reaction in the control and test group after the challenge procedure performed with 2,4,6,8,10-Pentamethylcyclopentasiloxane at 15% in acetone. The acetone, itself, did not show any local skin reactions and was, therefore, considered to be suitable for this type of study.
Based on the findings observed in a non-adjuvant sensitization test in guinea pigs, 2,4,6,8,10-Pentamethylcyclopentasiloxane does not have to be classified and labelled as a skin sensitizer.
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