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EC number: 228-204-7 | CAS number: 6166-86-5
The acute toxicity of 2,4,6,8,10-Pentamethylcyclopentasiloxane when administered by a single oral gavage to rats was investigated according to OECD test guideline No. 420 and Commission Regulation (EC) No. 440/2008, B.1.
To determine the dose level investigated in the main study, a sighting study was conducted with two animals (female RccHan:WIST (SPF) rat). The test item was administered neat as delivered by the Sponsor. The two animals were separately treated with the test item at the initial dose level of 300 or 2000 mg/kg bw by single oral gavage administration. The dosing volumes were 0.30 mL/kg (300 mg/kg) or 2.02 mL/kg (2000 mg/kg). In the main study, an additional four female animals were treated with the test item at the dose level of 2000 mg/kg bw.
The animals were examined daily during the acclimatization period and mortality, viability and clinical signs were recorded. All animals were examined for clinical signs within the first 30 minutes and approximately 1, 2, 3 and 5 hours after treatment on day 1 and once daily during test days 2-15. Mortality/viability was recorded within the first 30 minutes and approximately 1, 2, 3 and 5 hours after administration on test day 1 (with the clinical signs) and twice daily during days 2-15. Body weights were recorded on day 1 (prior to administration) and on days 8 and 15. All animals were necropsied and examined macroscopically.
All animals survived until the end of the study period.
In the sighting study slightly ruffled fur was observed in the animal dosed at 300 mg/kg from test day 3 to day 5, and in the animal dosed at 2000 mg/kg bw from 2 hours after administration to test day 3. In the main study four additional animals were administrated at 2000 mg/kg bw. Slightly to moderately ruffled fur was noted in one animal from 1 to 5 hours after administration. No clinical signs were observed in the three other animals throughout the entire observation period of the main study.
The body weight of the animals was within the range commonly recorded for this strain and age.
No macroscopic findings were recorded at necropsy.
2,4,6,8,10-Pentamethylcyclopentasiloxane did not show any evidence of toxicity at the dose level of 2000 mg/kg bw after single oral administration to five female rats, observed over a period of 14 days.
LD50 (female rat): greater than 2000 mg/kg bw
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