Registration Dossier
Registration Dossier
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EC number: 203-396-5 | CAS number: 106-42-3
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The lowest result is a 24 hour EC50 of 1 mg/L for o-xylene. (Galassi 1988, o-xylene). The estimated LL50 values from TLM QSAR were 8.730 - 11.076 mg/L.
The experimental value was used for chemical safety assessment.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1 mg/L
Additional information
Data are available on the acute toxicity of each of the xylene isomers to aquatic invertebrates. The study by Galassi et al (1988) follows OECD 202 and uses Daphnia magna, whilst Holcombe et al (1987) used a flow through system to expose different species (including Daphnia magna) simultaneously. Niederlehner et al (1998) used Ceriodaphnia dubia as the test organism. All studies included analytical confirmation of the exposure concentrations.
The 24 and 48 hour EC50 results reported from these studies for the different isomers are very similar, with a range of 1-4.7 mg/L. In the study by Niederlehner et al (1998) the highest concentration tested did not result in effects on mortality, so the EC50 is >3.4 mg/L. The most conservative result from the individual isomers will be used in the risk assessment, which is the 24 hour EC50 of 1 mg/L for o-xylene. (Galassi 1988)
A TLM-EqP modeling framework was used to support values derived experimentally and are presented as supporting studies.
The estimated LL50 values from TLM QSAR were 8.730 - 11.076 mg/L
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