1,4-diisopropylbenzene

Endpoint summary

Description of key information

Acute toxicity – oral/ rats
Slightly toxic in oral route. LD50 > 3200 mg/kg body weight in male and female rats.

 

Acute toxicity – inhalation
Not considered to be a relevant route of potential human exposure

Acute toxicity – dermal

Slightly toxic by the dermal route, LD50 > 20 mL/kg bw/d (= ca. 20000 mg/kg bw/d).

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

26 January 1982 - 16 April 1984

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods with acceptable restrictions

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Test type:

standard acute method

Specific details on test material used for the study:

TEST MATERIAL
- name as cited in test report: p-diisopropylbenzene
- Molecular weight: 162 g/mol
- Molecular formula: C12H18
- Physical state: liquid
- Boiling point: 208°C at 760 mmHg

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: not specified
- Stability with H+; OH-; Heat, Light, H2: given

Species:

rat

Strain:

not specified

Sex:

male/female

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Remarks:

100 % as received

Doses:

3200 mg/kg

Control animals:

no

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 3 200 mg/kg bw

Based on:

test mat.

Mortality:

No mortalities were observed.

Clinical signs:

other:

Gross pathology:

No necropsies were conducted

The acute oral LD50 of this compound was greater than 3200 mg/kg in male and female rats. Clinical signs of toxicity included slight to moderat weakness and rough coats.

Interpretation of results:

other: EU GHS criteria not met

Conclusions:

Based on the results of this study, the acute oral LD50 for test item was greater than 3200 mg/kg in male and female rats. Clinical signs of toxicity included slight to moderate weakness and rough coats. 

Executive summary:

An acute oral toxicity study was conducted on rats. Based on the results of this study, the acute oral LD50 for test item was greater than 3200 mg/kg in male and female rats. Clinical signs of toxicity included slight to moderate weakness and rough coats. 

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

> 3 200 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Link to relevant study records

Reference

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

26 January 1982 - 16 April 1984

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods with acceptable restrictions

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

no guideline followed

Principles of method if other than guideline:

The test was conducted according to an internal method.

GLP compliance:

not specified

Specific details on test material used for the study:

TEST MATERIAL
- name as cited in test report: p-diisopropylbenzene
- Molecular weight: 162 g/mol
- Molecular formula: C12H18
- Physical state: liquid
- Boiling point: 208 °C at 760 mmHg

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: not specified
- Stability with H+; OH-; Heat, Light, H2: given

Species:

guinea pig

Strain:

not specified

Sex:

not specified

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

occluded, single exposure, 24 hours
(guinea pig abdomen)

Duration of exposure:

24 hours

Doses:

single dose (dose up to 20 mL/kg)

Control animals:

no

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 20 mL/kg bw

Based on:

test mat.

Remarks on result:

other: = ca. 20000 mg/kg bw/d

Clinical signs:

other: erythema, edema, necrosis, eschars, scarring, desquamation and aloepcia

It produced moderate to severe erythema and edema and some necrosis initially; eschars were present after one week, and scarring, desquamation and alopecia were present after two weeks at doses ranging from 20 mL/g down to 1 mL/kg.

The dermal LD50 was greater than 20 mL/kg. 

Interpretation of results:

GHS criteria not met

Conclusions:

Based upon the results of this test, the acute dermal LD50 of test item was determined to be greater than 20 mL/kg bw (= ca. 20000 mg/kg bw/d).

Executive summary:

The acute toxicity to guinea pig in dermal test was performed. At most, test item is only slightly toxic by the dermal route. There was no evidence of percutaneous absorption. LD50 value was determined to be greater than 20mL/kg bw (= ca. 20000 mg/kg bw/d).

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

> 20 000 mg/kg bw

Additional information

Acute toxicity – oral
The acute toxicity of p-DIPB to rats in oral gavage test was performed. No compound-related effects were observed at gross pathology examination of the high-dose group of animals.

The compound was considered to be slightly toxic following oral administration. The LD50 value was greater than 3200 mg/kg body weight.

 

Acute toxicity – inhalation
Inhalation is not considered to be a relevant route of potential human exposure

Acute toxicity – dermal
The acute toxicity to guinea pig in dermal test was performed. At most, test item is only slightly toxic by the dermal route.

There was no evidence of percutaneous absorption. LD50 value was determined to be greater than 20 mL/kg bw (= ca. 20000 mg/kg bw/d).

Justification for classification or non-classification

Based on the available data, test item is not classified for acute toxicity according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No 1272/2008.