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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to birds

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Endpoint:
short-term toxicity to birds: acute oral toxicity test
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
Reason / purpose for cross-reference:
read-across source
Reference substance (positive control):
no
Key result
Duration (if not single dose):
14 d
Dose descriptor:
LC50
Effect level:
> 2 250 mg/kg bw
Conc. / dose based on:
test mat.
Basis for effect:
mortality
Mortality and sub-lethal effects:
There was an apparent dosage related effect on body weight of males at the 1350 mg/kg and 2250 mg/kg dosages for Days 0-3. There appeared to be no effect on feed consumption at any dosage.
Further details on results:
In conclusion, the acute oral LD50 value of SY-83 to the bobwhite for this study was determined to be greater than 2250 mg/kg, the highest dosage tested. There were no mortalities at any dosage tested. Based upon effects on male body weight at 1350 and 2250 mg/kg, the no- observed-effect dosage was 810 mg/kg.
Validity criteria fulfilled:
yes
Conclusions:
In conclusion, the acute oral LD50 value of SY-83 to the bobwhite for this study was determined to be greater than 2250 mg/kg, the highest dosage tested. There were no mortalities at any dosage tested. Based upon effects on male body weight at 1350 and 2250 mg/kg, the no- observed-effect dosage was 810 mg/kg.
Executive summary:

The acute oral LD50 value of SY-83 to the bobwhite for this study was determined to be greater than 2250 mg/kg, the highest dosage tested. There were no mortalities at any dosage tested. Based upon effects on male body weight at 1350 and 2250 mg/kg, the no- observed-effect dosage was 810 mg/kg. Since lactic acid is an essential molecule for life and has an extensive role in metabolism, this may be just a result of an equilibrium shift in metabolic pathways.

 

This information is used in a read-across approach in the assessment of the target substance. For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
Endpoint:
short-term toxicity to birds: dietary toxicity test
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Justification for type of information:
For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
Reason / purpose for cross-reference:
read-across source
Key result
Duration (if not single dose):
8 d
Dose descriptor:
LC50
Effect level:
> 5 620 mg/kg diet
Conc. / dose based on:
test mat.
Basis for effect:
mortality
Duration (if not single dose):
8 d
Dose descriptor:
NOEC
Effect level:
>= 5 620 mg/kg diet
Conc. / dose based on:
test mat.
Basis for effect:
other: external observations of (any) abnormality
Validity criteria fulfilled:
yes
Conclusions:
In conclusion, the LC50 of SY-83 to the bobwhite in this study was greater than 5620 ppm, the highest concentration tested. No apparent treatment related mortalities occurred. The no-observed-effect concentration was 5620 ppm.
Executive summary:

The LC50 of SY-83 to the bobwhite in this study was greater than 5620 ppm, the highest concentration tested. No apparent treatment related mortalities occurred. The no-observed-effect concentration was 5620 ppm.

This information is used in a read-across approach in the assessment of the target substance. For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
Endpoint:
short-term toxicity to birds: dietary toxicity test
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Justification for type of information:
For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
Reason / purpose for cross-reference:
read-across source
Key result
Duration (if not single dose):
8 d
Dose descriptor:
LC50
Effect level:
> 5 620 mg/kg diet
Conc. / dose based on:
test mat.
Basis for effect:
mortality
Duration (if not single dose):
8 d
Dose descriptor:
NOEC
Effect level:
>= 5 620 mg/kg diet
Conc. / dose based on:
test mat.
Basis for effect:
other: any external observation
Validity criteria fulfilled:
not specified
Conclusions:
In conclusion, the dietary LC50 value of SY-83 to the mallard in this study was greater than 5620 ppm, the highest concentration tested. The no-observed-effect concentration was also 5620 ppm.
Executive summary:

Controls - There were no mortalities in the control group. All birds were normal in appearance and behavior throughout the test period. SY-83 - There were no signs of toxicity, abnormal behavior or mortality in any test group. All birds were normal in appearance and behavior throughout the test period. When compared to the control, there was no effect on body weight or feed consumption throughout the test period. The dietary LC50 value of SY-83 to the mallard in this study was greater than 5620 ppm, the highest concentration tested. The no-observed-effect concentration was also 5620 ppm.

This information is used in a read-across approach in the assessment of the target substance. For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
Endpoint:
long-term toxicity to birds: reproduction test
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:

Description of key information

Since dilactide undergoes immediate hydrolysis in contact with water, forming lactic acid, this is the moiety of interest by read-across.

In view of the general lack of systemic toxicity of lactic acid, being an endogenous metabolite both in mammals and birds, a test of reproductive toxicity in birds is not considered to be required. Nevertheless, available studies on L(+)-lactic acid are used for read-across to evaluate the toxicity to birds.

In all three studies the substance seems not be toxic to birds:

LD50 (14d, Colinus virginiaunus) > 2250 mg/kg (highest dosage tested); no mortalities occured; NOEC (male weight) = 810 mg/kg

LC50 (8d, Colinus virginianus and 8d, Anas platyrhynchos) > 5620 ppm (highest dosage tested); no mortalities occurred; NOEC = 5620 ppm

Key value for chemical safety assessment

Additional information