Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Biodegradation in water: screening tests

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
biodegradation in water: ready biodegradability
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
For QMRF and QPRF please see the attached documents below.
Qualifier:
according to guideline
Guideline:
other: REACH guidance on information requirements and chemical safety assessment, chapter R.6: QSARs and grouping of chemicals, May 2008.
Deviations:
no
GLP compliance:
no
Specific details on test material used for the study:
- Name of test material (as cited in study report): Dilactide
- SMILES: CC1C(=O)OC(C(=O)O1)C (canonical)
Parameter:
probability of ready biodegradability (QSAR/QSPR)
Value:
1.027
Remarks on result:
other: QSAR calculation (BIOWIN)
Details on results:
Biowin1 (Linear Biodeg Probability): 1.0273
Biowin2 (Non-Linear Biodeg Probability): 0.9999
A Probability Greater Than or Equal to 0.5 indicates --> Biodegrades Fast
A Probability Less Than 0.5 indicates --> Does NOT Biodegrade Fast

Biowin3 (Survey Model - Ultimate Biodeg) 3.1611
Biowin4 (Survey Model - Primary Biodeg) 4.0977
Result Classification: 5.00 -> hours 4.00 -> days 3.00 -> weeks
(Primary & Ultimate) 2.00 -> months 1.00 -> longer

Biowin5 (MITI Linear Biodeg Probability) 0.9965
Biowin6 (MITI Non-Linear Biodeg Probability) 0.9542
A Probability Greater Than or Equal to 0.5 indicates --> Readily Degradable
A Probability Less Than 0.5 indicates --> NOT Readily Degradable

Biowin7 (Anaerobic Linear Biodeg Prob) 1.0995
A Probability Greater Than or Equal to 0.5 indicates --> Biodegrades Fast
A Probability Less Than 0.5 indicates --> Does NOT Biodegrade Fast

The prediction is not dependent on stereochemistry.
Validity criteria fulfilled:
not applicable
Interpretation of results:
readily biodegradable
Conclusions:
Dilactide is predicted to be readily biodegradable by the (Q)SAR model BIOWIN v4.10.
Executive summary:

Dilactide is predicted to be readily biodegradable by the (Q)SAR model BIOWIN v4.10.

Description of key information

Dilactide is considered to be readily biodegradable.

Key value for chemical safety assessment

Biodegradation in water:
readily biodegradable

Additional information

Dilactide is predicted to be readily biodegradable by the validated QSAR model BIOWIN v4.10.