Registration Dossier
Registration Dossier
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EC number: 202-468-3 | CAS number: 95-96-5
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Medium:
- other: sunflower oil
- Remarks on result:
- other: insoluble, particle disintegration observed under microscope
- Medium:
- other: silicone oil
- Remarks on result:
- other: insoluble, good dispersion
- Medium:
- other: kerosene
- Remarks on result:
- other: insoluble, but poor dispersion
- Medium:
- toluene
- Remarks on result:
- other: soluble
- Conclusions:
- D-lactide was found to be insoluble in kerosene, silicone oil and sunflower oils, but soluble in toluene.
- Executive summary:
The solubility of the test item in organic solvents was assesed in a GLP non-guideline study. A small quantity of the test item sample was added to 25 mL of different solvents and the mixtures were vortexed for 10 seconds. D-lactide is insoluble in kerosene, silicone oil and vegetable oils, but soluble in toluene.
This information is used in a read-across approach in the assessment of the target substance. For justification of read-across please refer to the attached read-across report (see IUCLID section 13).
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Medium:
- other: sunflower oil
- Solubility:
- other: insoluble
- Remarks on result:
- other: insoluble, well dispersed
- Medium:
- other: silicone oil
- Solubility:
- other: insoluble
- Remarks on result:
- other: insoluble, well dispersed
- Medium:
- other: kerosene
- Solubility:
- other: insoluble
- Remarks on result:
- other: insoluble, but poor dispersion stability
- Medium:
- toluene
- Solubility:
- other: soluble
- Conclusions:
- In conclusion, it can be stated that L-lactide is insoluble in kerosene, silicone oil and vegetable oils, but soluble in toluene.
- Executive summary:
The solubility of the test item in organic solvents was assesed in a GLP non-guideline study. A small quantity of the test item sample was added to 25 mL of different solvents and the mixtures were vortexed for 10 seconds. L-lactide is insoluble in kerosene, silicone oil and vegetable oil, but soluble in toluene.
This information is used in a read-across approach in the assessment of the target substance. For justification of read-across please refer to the attached read-across report (see IUCLID section 13).
Referenceopen allclose all
Description of key information
The solubility of the test items in organic solvents was assessed in a GLP non-guideline study. A small quantity of the test item sample was added to 25 mL of different solvents and the mixtures were vortexed for 10 seconds. L-lactide and D-lactide are insoluble in kerosene, silicone oil and vegetable oil, but soluble in toluene. L-lactide and D-lactide are suitable read across partners as dilactide is a mixture of D- and L-lactide isomers.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
