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EC number: 202-468-3 | CAS number: 95-96-5
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Medium:
- other: sunflower oil
- Remarks on result:
- other: insoluble, particle disintegration observed under microscope
- Medium:
- other: silicone oil
- Remarks on result:
- other: insoluble, good dispersion
- Medium:
- other: kerosene
- Remarks on result:
- other: insoluble, but poor dispersion
- Medium:
- toluene
- Remarks on result:
- other: soluble
- Conclusions:
- D-lactide was found to be insoluble in kerosene, silicone oil and sunflower oils, but soluble in toluene.
- Executive summary:
The solubility of the test item in organic solvents was assesed in a GLP non-guideline study. A small quantity of the test item sample was added to 25 mL of different solvents and the mixtures were vortexed for 10 seconds. D-lactide is insoluble in kerosene, silicone oil and vegetable oils, but soluble in toluene.
This information is used in a read-across approach in the assessment of the target substance. For justification of read-across please refer to the attached read-across report (see IUCLID section 13).
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Medium:
- other: sunflower oil
- Solubility:
- other: insoluble
- Remarks on result:
- other: insoluble, well dispersed
- Medium:
- other: silicone oil
- Solubility:
- other: insoluble
- Remarks on result:
- other: insoluble, well dispersed
- Medium:
- other: kerosene
- Solubility:
- other: insoluble
- Remarks on result:
- other: insoluble, but poor dispersion stability
- Medium:
- toluene
- Solubility:
- other: soluble
- Conclusions:
- In conclusion, it can be stated that L-lactide is insoluble in kerosene, silicone oil and vegetable oils, but soluble in toluene.
- Executive summary:
The solubility of the test item in organic solvents was assesed in a GLP non-guideline study. A small quantity of the test item sample was added to 25 mL of different solvents and the mixtures were vortexed for 10 seconds. L-lactide is insoluble in kerosene, silicone oil and vegetable oil, but soluble in toluene.
This information is used in a read-across approach in the assessment of the target substance. For justification of read-across please refer to the attached read-across report (see IUCLID section 13).
Referenceopen allclose all
Description of key information
The solubility of the test items in organic solvents was assessed in a GLP non-guideline study. A small quantity of the test item sample was added to 25 mL of different solvents and the mixtures were vortexed for 10 seconds. L-lactide and D-lactide are insoluble in kerosene, silicone oil and vegetable oil, but soluble in toluene. L-lactide and D-lactide are suitable read across partners as dilactide is a mixture of D- and L-lactide isomers.
Key value for chemical safety assessment
Additional information
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