Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-868-0 | CAS number: 111-42-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Acutely harmful to aquatic invertebratesKey value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Remarks:
- 48 h
- Effect concentration:
- 30.1 mg/L
Additional information
A static acute immobilisation study performed according to ASTM Standard E729-80 with Ceriodaphnia dubia as test organism was selected as key study (Cowgill et al., 1985). The 48-h EC50 was determined to be 30.1 mg/L.
The lowest reliable value for acute toxicity to Daphnia magna was reported from a static test according to US EPA Guideline 600/3-75-009 (LeBlanc, 1980). Based on nominal concentrations, the 48-h EC50 was 55 mg/l. However, since measured pH values ranged from 7.4 to 9.4, alkaline pH effects might have contributed to the observed mortality.
In addition, the acute toxicity of diethanolamine to Daphnia magna was investigated in a 48-hour static test according to OECD TG 202. Based on nominal concentrations, the 48 hour EC50 was 171 mg/l (Zurita et al., 2005).
Further, the effect of diethanolamine on Hyalella azteca was studied according to an Environment Canada method (PTAC, 2006). 50 animals were exposed to a series of 5 test concentrations and observed over 96 h and dead neonates counted after 48 and 96 h. The 96-h LC50 was determined to be 344 mg/L (95% CL: 312 -377 mg/L; nominal, analytically verified).
Some of the studies were performed without analytical monitoring, however, from the available acute and chronic toxicity studies on fish, aquatic invertebrates and algae, conducted with analytical monitoring (PTAC, 2006; BASF AG, 1992, Rep. no 92/1444/51/1; Libralato, 2010), it can be deduced that diethanolamine is rather stable in static test systems for at least 48 hours. Moreover, the stability of diethanolamine in the test medium is considered to be stable due to the high water solubility (WS = 1E+06 mg/L), the low vapour pressure (VP = 8.5E-05 hPa at 20°C) and the low Henry´s law constant (HLC (uncharged): 3.97E-06 Pa*m3/mol; pH-corrected HLC (pH 5-9): 4.06E-10 to 2.01E-06 Pa*m3/mol) of the substance.
Based on the available data diethanolamine is considered to be acutely harmful to aquatic invertebrates.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
