Registration Dossier
Registration Dossier
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EC number: 203-468-6 | CAS number: 107-15-3
Endpoint summary
Administrative data
Description of key information
Skin and eye irritation tests with rabbits show that ethylene diamine is corrosive to skin and eye; there is no study available for respiratory irritation.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Based on the available data for skin corrosion, ethylene diamine is shown to be corrosive to skin. A 1 -min exposure showed necrosis at observation after 24h.
Irreversible damage to eye after exposure was shown in a study. Observations were made after 10 min, 1 and 3 h on the day of treatment and up to 8 days afterwards. The eyes were not washed out after 24 hours as specified in OECD Guideline 405.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Ethylene diamine is classified as corrosive cat 1B to skin and corrosive to eye according to harmonised EU classification, and the available data supports this classification.
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