Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Skin and eye irritation tests with rabbits show that ethylene diamine is corrosive to skin and eye; there is no study available for respiratory irritation.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irreversible damage)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Based on the available data for skin corrosion, ethylene diamine is shown to be corrosive to skin. A 1 -min exposure showed necrosis at observation after 24h.

Irreversible damage to eye after exposure was shown in a study. Observations were made after 10 min, 1 and 3 h on the day of treatment and up to 8 days afterwards. The eyes were not washed out after 24 hours as specified in OECD Guideline 405.

Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: corrosive

Justification for classification or non-classification

Ethylene diamine is classified as corrosive cat 1B to skin and corrosive to eye according to harmonised EU classification, and the available data supports this classification.