Registration Dossier
Registration Dossier
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EC number: 482-430-2 | CAS number: -
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Details on test material:
- Physical form of substance: L
Mass median aerodynamic diameter (for liq.+solid aerosol):
2.11um
Constituent 1
Test animals
- Species:
- other: Rat (Sprague-Dawley)
Administration / exposure
- Vehicle:
- other: None
- Details on inhalation exposure:
- Nose only
- Duration of exposure:
- 4 h
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.13 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- Male: 5.13 mg/L; Number of animals: 5; Number of deaths: 1
Female: 5.13 mg/L; Number of animals: 5; Number of deaths: 1 - Clinical signs:
- other: Signs of toxicity related to dose levels: During exposure, decreased respiratory rate was noted in all animals and there were occasional instances of laboured respiration. On removal from the chamber, animals showed decreased respiratory rate and ther
- Gross pathology:
- Effects on organs:
The lungs of the two animals that died during the study were
found to be filled with fluid and pale or abnormally dark
or with dark patches.
No macroscopic abnormalities were detected in the animals
that survived until the study ended.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified in accordance with EU criteria
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