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EC number: 482-430-2 | CAS number: -
A GLP study was performed to assess the acute oral toxicity of Inhibitor AHM P500 following a single oral administration to the Sprague-Dawley CD rat. The method was designed to meet the requirements OECD guideline 423.
A group of three fasted females was treated with the test material at a dose level of 2000 mg/kg bodyweight. Based on the results from this dose level, further groups of fasted females were treated at a dose level of 300 mg/kg bodyweight. Dosing was performed sequentially.
The test material was administered orally undiluted for the 2000 mg/kg dose level and orally as a solution in arachis oil BP for the 300 mg/kg dose level. Clinical signs and bodyweight development were monitored during the study. All animals were subject to gross necropsy.
All animals treated at a dose level of 2000 mg/kg were found dead approximately two and half hours after dosing. There were no deaths noted in animals treated at a dose level of 300 mg/kg.
Signs of systemic toxicity noted in animals treated at a dose level of 2000 mg/kg were hunched posture, lethargy, ataxia, ptosis, decreased respiratory rate, laboured respiration, increased salivation, splayed gait, loss of righting reflex and hypothermia. There were no signs of systemic toxicity noted in animals treated at a dose level of 300 mg/kg.
The surviving animals showed expected bodyweight gain over the study period.
Abnormalities noted at necropsy of animals that died during the study were abnormally red lungs, dark liver and dark kidneys. No abnormalities were noted at necropsy of animals that were killed at the end of the study.
The acute oral median lethal dose (LD50) of the test material in the female Sprague-Dawley CD strain rat was approximately 500 mg/kg bodyweight (GHS Category 4 >300-2000 mg/kg bodyweight).
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