Registration Dossier

Administrative data

Endpoint:
pH
Type of information:
experimental study
Adequacy of study:
key study
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2006
Report Date:
2006

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
other: CIPAC MT75
Qualifier:
according to
Guideline:
CIPAC MT 75 (Determination of pH Values)
Deviations:
no
GLP compliance:
yes (incl. certificate)

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: Liquid

Results and discussion

pH value
pH value:
9.4
Temp.:
20 °C
Concentration:
other: Undiluted

Applicant's summary and conclusion

Conclusions:
The pH of undiluted Inhibitor AHM P500 was pH 9.4.
Executive summary:

A GLP guideline study was performed to determine the physical-chemical properties of Inhibitor AHM P500.

The following properties were determined; appearance, boiling point, relative density, solubility in water, octanol/water partition coefficient, pH, flash point.

The appearance of the test substance was determined in accordance with OPPTS 830.6302, 830.6303 and 830.6304. The test substance is a liquid of low non distinctive odour. The colour, as described using the Munsell colour system, was 10R 3/6 Dark Red.

 

The boiling point was determined in duplicate using the Siwoloboff method as described in EEC Method A2. The test substance decomposed before boiling therefore no definitive value was determined.

The relative density was determined at 20±1°C using a glass hydrometer, in accordance with EEC Method A3. The mean value of duplicate determinations was 0.935.

The water solubility was determined in accordance with OECD guideline 105 using the flask method. Determination of the test substance in the aqueous phase was by HPLC with UV detection. The analytical method for the determination of Inhibitor AHM P500 solubility in water was validated for linearity, accuracy, precision and selectivity. The method validation met the criteria specified in the study plan and was considered acceptable for use.

The water solubility of the test substance was 2.22 g/L at 20±1°C.

The octanol/water partition coefficient was determined in accordance with OECD guideline 117 using HPLC with UV detection. A Log Pow value of 3.24 was determined.

The pH of undiluted test material was measured at 20±1°C using a calibrated pH meter and glass electrode in accordance with CIPAC Method 75. The mean of duplicate determinations was 9.4. The pH of 1% solution in water was not determined due to the lack of water solubility of the test substance in water. The pH of a saturated aqueous solution, as measured during the water solubility determination, was pH 10.7.

The flash point was determined using the closed cup method in accordance with EU method A9. The mean result of duplicate determinations was 124°C.