Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-765-0 | CAS number: 7722-84-1
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- repeated dose toxicity: other route
- Adequacy of study:
- supporting study
Data source
Reference
- Title:
- No information
- Author:
- Kondrashov, V.A.: Evaluation of the toxicity of hydrogen|peroxide vapors for inhalation and percutaneous exposures.|Gig Tr Prof Zabol 1977;21(10):22-25. [Russian, English|translation]
Materials and methods
- Principles of method if other than guideline:
- Method: other: Subchronic study (4 months, 5 h per day, 5 d a week) using combined inhalation and dermal (hair was clipped) exposure were conducted with rats. Exposures to H2O2 vapours were conducted on 874 white rats weighing 150-250 g.
- GLP compliance:
- no
Test material
- Reference substance name:
- Hydrogen peroxide
- EC Number:
- 231-765-0
- EC Name:
- Hydrogen peroxide
- Cas Number:
- 7722-84-1
- Molecular formula:
- H2O2
- IUPAC Name:
- hydrogen peroxide
- Details on test material:
- IUCLID4 Test substance: other TS: hydrogen peroxide, no further detail
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: inhalation (and dermal)
- Duration of treatment / exposure:
- 2-4 months
- Frequency of treatment:
- 5 h per day, 5 d per week up to 4 months
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.1 - 10.1 mg/m3 (vapour)
- Control animals:
- other: no data specified
- Details on study design:
- Post-exposure period: not given
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
Effects: The threshold concentration of H2O2 vapours for the respiratory organs was shown to be 10 mg/m3, the no-effect concentration was 1 mg/m3. At two and three months of exposure to 10 mg/m3 an increase was noted in the serum epoxidase activity (2.50 and 2.63, respectively, in the control animals 2.16 and 2.20). After 4 months the lungs showed a decrease of succinate dehydrogenase activity (SDH) (0.26 among exposed animals versus 0.34 in controls). After 4 months, histoenzymological studies of the lungs revealed a decrease in the activities of SDH, monoamine oxidase (MAO), acid phosphatase, diesterase, and an increase in the activity of alkaline phosphatase.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
