Registration Dossier

Administrative data

Description of key information

Minimally irritating.

Key value for chemical safety assessment

Additional information

Neodecanoic acid is minimally but transiently irritating to the skin and eyes.

 

In skin irritation studies, mild and transient erythema and edema are noted in animals. However, these reactions were fully reversible within 7 days post exposure. After, 7 days, desquamation was noted. 

 

In eye irritation studies, 1 hour after treatment, animals typically show a slight redness of the conjunctivae, slight to moderate swelling and slight to moderate discharge. Recovery typically occurs within 48 hours after treatment and is fully resolved by 72 hours.

 

In a study to assess respiratory irritation, mice received 30 minute head only exposures to average actual concentrations of 3607 (group 1), 1098 (group 2), or 334 (group 3) mg/m3 of neodecanoic acid. The group 1 mean respiratory rate was depressed 42.5% below the pre-exposure rates, while the group 2 rate was decreased 24.9 %. The group 3 sample respiratory rate was increased by 7.9%. One of the group 1 mice died approximately 16 minutes after the start of the exposure. The three surviving mice displayed both sensory and pulmonary responses. Although a 50% reduction in respiratory rate was not achieved, a RD50 based on the three exposure groups was estimated as 5491 mg/m3.


Effect level: empty Endpoint conclusion: Adverse effect observed

Effect level: empty Endpoint conclusion: Adverse effect observed

Effect level: empty Endpoint conclusion: Adverse effect observed

Justification for classification or non-classification

No classification for skin/eye irritation or corrosion is indicated according to the general classification and labeling requirements for dangerous substances and preparations (Directive 67-548-EEC) or the classification, labeling, and packaging (CLP) regulation (EC) No 1272/2008.