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EC number: 605-296-0 | CAS number: 162627-17-0
There were no deaths, no signs of ill health or toxicity and no signs of local irritation over the treated area during the main study. Greasy fur was noted for all control and test animals post-dose from Day 1 and was still seen on Day 6.
Bodyweight loss, marginal in degree, was recorded for one main study animal of the vehicle control group and three of the 10% w/v dose group and stable bodyweight for one animal of the 5% w/v dose group. All other animals gained bodyweight during the main study.
Stimulation indices of 4.1, 5.7 and 8.9 were attained after induction treatment with WS400130 at 2.5, 5 and 10% (w/v), respectively. From the stimulation indices attained at the two lower doses an EC3ex value* of 1.6% w/v was calculated by log-linear extrapolation.
In a local lymph node assay with mice, the stimulation index (SI) threshold of ≥ 3.0, indicating a positive sensitisation response, was attained in all treated groups. The EC3ex value was calculated to be 1.6% w/v. Therefore, according to EU classification rules the test substance was classified as “Skin sensitisation Category 1, subcategory 1A” [REGULATION (EC) 1272/2008].
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