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EC number: 219-941-5 | CAS number: 2579-20-6
Corrosive effects seen in albino rabbit following 3 minutes' dermal exposure. Substance is therefore considered corrosive and eye irritation studies subsequently considered unjustified.
A study was performed to assess the irritancy potential of the test material to the skin of the New Zealand White rabbit. The method used followed the recommendations of the OECD Guidelines for Testing of Chemicals No. 404 "Acute Dermal Irritation/Corrosion" (adopted 17 July 1992) and Method B4 of Commission Directive 92/69/EEC (which constitutes Annex V of Council Directive 67/548/EEC).
A single 3-minute semi-occluded application of the test material to the intact skin of one rabbit produced corrosive effects.
4-hour and 1-hour semi-occluded applications of the test material to the intact skin were therefore not investigated.
The results of observation of dermal symptoms at 3 minutes, 60 minutes and 4 hours after application are illustrated in Table 1. In rats, the skin surfaces changed color (dark brown) and subcutaneous hemorrhage occurred from 1.5 minutes after application; these lesions were further aggravated as they were macroscopically judged to be necrosis after 3 minutes. The skin surfaces manifested highly necrotic appearances after 60 minutes; namely, dark red brown lesions were slightly dried and hardened.
In the observation of cut surfaces of the skin at 4 hours after application, necrosis appeared throughout the entire dermal layers and hemorrhage as severe as it reached the dorsal muscle.
Er=erythema; Ed= edema; H=hemorrhage; N=necrosis Severity: 0= normal; 1= very mild; 2= mild; 3= moderate; 4=severe
Table. Primary irritative symptoms in the skin
Body Weight (g)
Crj Wistar rats (6 weeks)
A skin corrosive test founded on the standards of the United Nations was performed in accordance with "the test methods and evaluation criteria in the evaluation of danger of unkown substances" established by the Maritime Techniques Safety Bureau, Ministry of Transport (December 1985), in order to determine whether or not 1,3 -BAC corresponded to a corrosive substance (class 8) defined in the recommendations of the United Nations concerning the transport of dangerous substances.
As a result, the test substance was judged in accordance with the criteria of the International Maritime Organization (IMO) to corespond to a corrosive substance defined in the recommendations of the United Nations concerning the transport of dangerous substances.
A primary skin irritation test was conducted on albino rabbits to compare and determine the strength of primary skin irritation of MXDA-based epoxy resin hardeners. The test results showed corrosive skin lesions induced by 1,3 -BAC.
Three studies have been reported, all of which indicate the corrosive nature of the substance.
The key study (SafePharm 1998) was conducted to OECD 404 and under GLP, and showed skin corrosion.
A second study (Niigata Laboratories, 1986) was conducted according to UN methods for skin corrosion and also shows corrosive effects.
A third study (Niigata Laboratories, 1984) was a skin irritation study which also showed irritant / corrosive effects.
The substance is therefore considered to be corrosive to both skin and eyes.
Effects on skin irritation/corrosion: corrosive Effects on eye irritation: corrosive
Corrosive effects were reported following 3 minutes' exposure to the skin of one rabbit; observation was carried out up to 1 hour after exposure. On this basis, the classification according to CLP (EC Regulation 1272/2008, employing the GHS system for classification) is corrosive category 1A.
Note that when corrosive category 1A is applied according to CLP, Irreversible effects on the eye Category 1 also applies.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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