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Physical & Chemical properties

Vapour pressure

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Description of key information

A vapour pressure study carried out on the reference substance (Tremain, 2007) gave a determination of 8.6 x 10 E-10Pa at 25°C.

A second study carried out on an analogue substance (Taylor, 1996) gave a determination of 7.0 x10 E-5Pa.

Key value for chemical safety assessment

at the temperature of:
25 °C

Additional information

A vapour pressure study carried out on the reference substance (Tremain, 2007) gave a determination of 8.6 x 10-10 Pa at 25°C. A second study carried out on an analogue substance (Taylor, 1996) gave a determination of 7.0 x 10-5 Pa.

Both studies were conducted to the same standards and therefore considered to be reliable however as the first study (Tremain, 2007) was carried out on the substance of interest this was considered to be the key study for the purposes of this assessment.

Tremain 2007:

The vapour pressure was determined using a vapour pressure balance with measurements being made at several temperatures and linear regression analysis used to calculate the vapour pressure at 25°C. Testing was conducted using Method A4 of Commission Directive 92/69/EEC (which constitutes Annex V of Council Directive 67/548/EEC).

The vapour pressure of the test material has been determined to be 8.6 x 10-10Pa at 25°C.

Taylor 1996: This study was performed on Abacavir Succinate and has been used for read-across purposes.

The vapour pressure of the test material was determined on the 24th October 1996 using the vapour pressure balance method, Method A4 as published in 92/69/EEC. The recommended maximum vapour pressure was 7.0 x10-5Pa.