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Short-term toxicity to fish

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Description of key information

The 96-h LC50 is > 100mg/L in zebra fish.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
100 mg/L

Additional information

The acute toxicity of the test substance to zebra fish (Brachydanio rerio) was determined in a 96-hour static test according to the EU Commission Directive 92/69/EEC, Part C.1 (1992), and the OECD Guideline for Testing of Chemicals No. 203, (1992) under GLP. A limit test was performed in accordance with the guidelines to demonstrate that the test item has no toxic effect on the test organisms at the nominal concentration of 100 mg/L. Thus the only concentration tested was nominal 100 mg/L and a control. The analytically determined concentration of the test substance in the test medium varied in the range from 104 to 108% of the nominal value. The test substance was stable under the conditions of the test during the test period of 96 hours. Therefore, all reported biological results are related to the nominal concentration of the test item.

In the control and at the test concentration of 100 mg/L no mortality or other visible abnormalities were determined at the test fish during the test period of 96 hours. Therefore, the 96-hour NOEC (highest concentration tested without toxic effects after the exposure period of 96 hours), and the 96-hour LC0 to zebra fish were determined to be at least 100 mg/L. The NOEC and the LC0 might even be higher than this concentration, but concentrations in excess of 100 mg/L have not been tested, according to the guidelines. The 96-hour LOEC (lowest concentration with toxic effects), the 96-hour LC50 and the 96-hour LC100 were clearly higher than 100 mg/L. These values could not be quantified due to the absence of toxicity at the tested concentration.