Registration Dossier
Registration Dossier
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EC number: 700-413-2 | CAS number: 6331-96-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Principles of method if other than guideline:
- No deviations from Guideline.
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-amino-4,5-dichlorobenzene-1-sulfonic acid
- EC Number:
- 700-413-2
- Cas Number:
- 6331-96-0
- Molecular formula:
- C6 H5 Cl2 N O3 S
- IUPAC Name:
- 2-amino-4,5-dichlorobenzene-1-sulfonic acid
- Test material form:
- other: solid
- Details on test material:
- Content of test item: 98.9% (not used for calculations)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Remarks:
- 400
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 6; three animals were used for each step.
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- discriminating dose
- Effect level:
- >= 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- other: cut-off LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
Clinical Signs: No clinical signs were observed
Body Weights: There were no toxicologically significant effects on body
weight or body weight gam.
Gross Pathology Findings: The necropsies performed at the end of the
study revealed no particular findings
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
According to OECD guideline 423 the LD50 cut-off of Dichlororthanilsaure is > 5000 mg/kg bw. According to EU Directive 67 /548/EEC and EC Regulation 1272/2008 the test item is unclassified. So it is regarded as non-toxic after oral application.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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