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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

According to OECD guideline 423 the LD50 cut-off of Dichlororthanilsaure is > 5000 mg/kg bw.  So it is regarded as non-toxic after oral application.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2012
Reliability:
1 (reliable without restriction)
Qualifier:
according to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
Deviations:
no
Principles of method if other than guideline:
No deviations from Guideline.
GLP compliance:
yes (incl. QA statement)
Test type:
acute toxic class method
Limit test:
yes
Species:
rat
Strain:
Wistar
Sex:
female
Route of administration:
oral: gavage
Vehicle:
polyethylene glycol
Remarks:
400
Doses:
2000 mg/kg
No. of animals per sex per dose:
6; three animals were used for each step.
Control animals:
no
Sex:
female
Dose descriptor:
discriminating dose
Effect level:
>= 2 000 mg/kg bw
Based on:
test mat.
Sex:
female
Dose descriptor:
other: cut-off LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.

Clinical Signs: No clinical signs were observed

Body Weights: There were no toxicologically significant effects on body weight or body weight gam.
Gross Pathology Findings: The necropsies performed at the end of the study revealed no particular findings

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Executive summary:

According to OECD guideline 423 the LD50 cut-off of Dichlororthanilsaure is > 5000 mg/kg bw. According to EU Directive 67 /548/EEC and EC Regulation 1272/2008 the test item is unclassified. So it is regarded as non-toxic after oral application.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating dose
Value:
2 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for selection of acute toxicity – oral endpoint
Guideline study

Justification for classification or non-classification

According to OECD guideline 423 the LD50 cut-off of Dichlororthanilsaure is > 5000 mg/kg bw. According to EU Directive 67 /548/EEC and EC Regulation 1272/2008 the test item is unclassified.