Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: OECD 403
GLP compliance:
yes
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Physical form of substance: S
Mass median aerodynamic diameter (for liq.+solid aerosol):
in der niederen Konzentrationsgruppe: (MMAD): .apprxeq. 5 µm
in der höheren Konzentrationsgruppe: (MMAD): .apprxeq. 10 µm

Test animals

Species:
other: rat, Wistar Hsd Cpb:WU (SPF)

Administration / exposure

Vehicle:
other: nicht verwendet "ENGLISH" not used
Details on inhalation exposure:
Nur-Nase-Exposition, dynamische Expositionsbedingungen
Duration of exposure:
4 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 5.04 mg/L air
Exp. duration:
4 h
Mortality:
Male: .23 mg/L; Number of animals: 5; Number of deaths: 0
Male: 5.04 mg/L; Number of animals: 5; Number of deaths: 0
Female: .23 mg/L; Number of animals: 5; Number of deaths: 0
Female: 5.04 mg/L; Number of animals: 5; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: Keine behandlungsbedingten klinischen Symptome. Reflexe am 1. Tag post expositionem unauffällig. Rektale Körpertemperaturen nicht signifikant beeinflußt. Körpergewichte und Körpergewichtszunahmen gegenüber der
Gross pathology:
Effects on organs:
Kein konzentrationsabhängiger Anstieg der Inzidenz von
makroskopisch-pathologischen Veränderungen bei den am Ende
der Nachbeobachtungszeit getöteten Tieren zu beobachten.

"ENGLISH"

no concentration-dependent rise of the incidence of
macroscopic-pathological changes with the animals killed

at the end of the observation-time after the experiment.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU