Registration Dossier
Registration Dossier
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EC number: 203-450-8 | CAS number: 106-99-0
Endpoint summary
Administrative data
Description of key information
1,3-Butadiene is a flammable gas at room temperature and therefore conventional skin and eye irritation studies cannot be carried out. The available data indicate that 1,3-butadiene is not irritating to skin or eyes. In liquid form it may cause burns and frostbite due to extreme cold.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no study available
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In accordance with REACH Annexes VII and VIII column 2 adaptation, studies on skin and eye irritation do not need to be conducted as the substance is flammable in air at room temperature. No skin studies have been conducted with 1,3 -butadiene and there is no indication from other studies in animals that 1,3-butadiene is irritating to the skin. In liquid form it may cause burns and frostbite due to extreme cold.
Limited data are available on the effect of 1,3-butadiene on the eye. Exposure of rabbits and dogs to 6,700ppm (14,824 mg/m3) for 7.5 h/day for 6 days/week for 8 months had no effect on the eyes (Carpenter et al, 1944). Humans exposed to 2000 ppm (4425 mg/m3) and 4000 ppm (8851 mg/m3) 1,3-butadiene described slight smarting of the eyes and difficulty in focusing although at 8000 ppm (17701 mg/m3) no subjective symptoms were reported (Carpenter et al, 1944). The EU RAR (2002) reports that eye irritation has been noted in humans exposed to very high concentrations of 1,3-butadiene although in these cases there was mixed exposure to other chemicals too. No eye irritation was reported in the chronic inhalation biaassay studies in mice and rats exposed to 1,250 and 8,000 ppm (2765 and 17701 mg/m3) respectively
In conclusion, the available data indicate that 1,3-butadiene is not irritating to skin or eyes.
Justification for classification or non-classification
1,3 -Butadiene is a flammable gas at room temperature and therefore inhalation exposure is the only relevant route. 1,3 -Butadiene is non-irritating and does not warrant classification under Dir 67/548/EEC or GHS/CLP
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