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Toxicological information

Immunotoxicity

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Description of key information

No persistent immunological defects were detectable after inhalation exposure to 1250 ppm (2765 mg/m3) 1,3-butadiene.

Key value for chemical safety assessment

Additional information

The effect of 1,3-butadiene on immune function in mice was investigated by Thurmond et al (1986). B6C3F1 Mice were exposed to 1250 ppm (2766 mg/m3) 1,3-butadiene by inhalation 6 h/day, 5 days/ week, for 6 or 12 weeks. Immune function assays were selected to evaluate specific humoral and cell-mediated immunity and spontaneous cytotoxicity, lymphoid organ histopathology was also evaluated. Significant extramedullary haematopoiesis and erythroid hyperplasia was observed in spleens from exposed mice, and correlated with a two-fold increase in thymidine incorporation in spontaneously proliferating splenocytes. Cytotoxic T-lymphocyte generation was suppressed after a 6-week exposure to 1,3-butadiene, but was comparable to controls after 12 weeks of exposure. Overall, no persistent immunological defects were detectable after inhalation exposure to 1250 ppm (2765 mg/m3) 1,3-butadiene.

Justification for classification or non-classification

1,3-Butadiene is not immunotoxic and does not warrant classification under Dir 67/548/EEC or GHS.