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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: acceptable, well-documented publication which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1988
Report date:
1988

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Pentacarbonyliron
EC Number:
236-670-8
EC Name:
Pentacarbonyliron
Cas Number:
13463-40-6
Molecular formula:
C5FeO5
IUPAC Name:
pentacarbonyliron
Details on test material:
purity >99.5%

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals or test system and environmental conditions:
The animals were identified via ear tattoo. The animals were housed in fully air-conditioned rooms. Central air-conditioning guaranteed a range of 20 - 24°C for temperature and of 30 - 70% for relative humidity. There were no deviations from these ranges which influenced the results of the study.
No bedding were used (saw-dust in the waste trays). Diet was Kliba 341 and drinking water was about 250 ml per animals and day. The acclimatization period was at least 8 days before beginning of the study with the same housing conditions as during the test period.

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
other: untreated skin of the same animal
Amount / concentration applied:
0.5 ml
Duration of treatment / exposure:
4 h
Observation period:
72 h
Number of animals:
3
Details on study design:
Clipping of the fur was at least 15 h before the beginning of the study. The application site was the upper third of the back or flanks. Removal of the test substance: at the end of the exposure period with Lutrol and Lutrol/water (1:1). The observation period was 72 h and readings were done 30 - 60 min after removal of the test patches and 24, 48, 72 h after the beginning of the application.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24-72 h
Score:
0
Max. score:
0
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24-27 h
Score:
0
Max. score:
0

Any other information on results incl. tables

Very slight to well-defined redness was observed 4 hours after application. These effects were reversible within 24 h. No effects on edema. One animal died after 72 h after application. This death was not substance-related.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information