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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: early study report, basic information given

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1958
Report date:
1958

Materials and methods

Principles of method if other than guideline:
The approximative dose (ALD50) was determined according to the methods of Behrens (cited in J.H. Burn: Bthol. Standardization, 1937).
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Pentacarbonyliron
EC Number:
236-670-8
EC Name:
Pentacarbonyliron
Cas Number:
13463-40-6
Molecular formula:
C5FeO5
IUPAC Name:
pentacarbonyliron
Details on test material:
no further data

Test animals

Species:
rat
Strain:
other: "normal"
Sex:
female
Details on test animals or test system and environmental conditions:
The mean body weights of the rats was 135.8 g.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: aqueous emulsion with 1% Traganth
Doses:
2.0, 7.9, 15.9, 20.4, 25.1, 31.6, 40, 63, 316 mg/kg
No. of animals per sex per dose:
5
Control animals:
yes
Details on study design:
- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
approximate LD50
Effect level:
ca. 25 mg/kg bw
Mortality:
All high-dosed animals died after 48 hours. No deaths were observewd in the three low dose groups (for details see table below).
Clinical signs:
The animals showed no remarkable symptoms before application.
The toxic symptoms were unspecific. The animals were apathetic and atonic after the application, breathing was accelerated and frequently intermittent.
Body weight:
no remarkable changes
Gross pathology:
The lethal contaminated animals died not acutely, but within 1 - 4 days. The surviving animals were killed after 14 days and necropsied. No pathological changes were observed macroscopically at the organs.

Any other information on results incl. tables

Mortality:

 Dose (mg/kg)  Mortality after        untreated control
   24 hours  48 hours  7 hours  
 316  3/5  5/5  5/5  
 63 (first dosage)  3/5  5/5  5/5  
 63 (second dosage)  0/5  0/5  1/5  
 40 (first dosage)  0/5  1/5  2/5  
 40 (second dosage)  5/5  5/5  5/5  12/12
 31.6  0/5  4/5  4/5  7/8
 25.1  0/5  0/5  1/5  3/8
 20.4  0/5  1/5  2/5  2/10
 15.9  0/5  0/5  0/5  
 7.9  0/5  0/5  0/5  
 2.0  0/5  0/5  0/5  

Applicant's summary and conclusion

Interpretation of results:
highly toxic
Remarks:
Migrated information