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Diss Factsheets
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EC number: 202-851-5 | CAS number: 100-42-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- other: biological monitoring
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication/report meeting basic scientific principles. Probabilistic modelling of dietary exposure.
Data source
Reference
- Reference Type:
- publication
- Title:
- Dietary exposure to chemical migrants from food contact materials: A probabilistic approach.
- Author:
- Holmes, M.J. et al.
- Year:
- 2 005
- Bibliographic source:
- Food Additives and Contaminations 22(10): 907-919
Materials and methods
- Type of study / information:
- A two-dimensional probabilistic model has been developed to estimate the short-term dietary exposure of UK consumers to migrants from food packaging materials.
- Principles of method if other than guideline:
- The model implements a two-dimensional Monte Carlo approach to explore the range of exposures the UK population may experience due to the migration of chemicals (including styrene) from packaging materials and calculates the daily dose.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Styrene
- EC Number:
- 202-851-5
- EC Name:
- Styrene
- Cas Number:
- 100-42-5
- Molecular formula:
- C8H8
- IUPAC Name:
- ethenylbenzene
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): styrene
- Analytical purity: no data
Results and discussion
Any other information on results incl. tables
In a recent study (FSA), 20 main total dietary study food groups were analysed for styrene. The limit of detection/limit of quantification values were 0.3 µg/kg and 1.0 µg/kg, respectively. In this study, the main food groups were used. To each group, the appropriate concentration dataset comprising of 5 data-points per group including non-detects and non-quantifiables were associated. The concentration data were associated on a 100 % market share basis with extrapolation factors and conversion factors set to unity. The simulated the scenario that if a food item in say the carcass meats groups were consumed it would take a sample from a nominal distribution constructed from the 5 data-points contained in the carcass meat concentration data. Using the two-dimensional Monte Carlo approach, the authors simulated the exposures due to the dietary consumption of the individiuals in three surveys.
The study comprised of homogenised samples of foods from each of the main food groups to determine migration levels. However, this means any correlation or contributions between high exposures and particular food items within food groups would be hidden.
In the FSA styrene study (FSA 1999), by multiplying the average consumption (using data from national dietary studies conducted in 1997) of the food groups by the mean level of styrene in each group, the average dietary exposure for a 60 kg individual was estimated. This was in the range, 0.03 -0.05 µg/kg bw/day, significantly less than the Maximum Tolerable Daily Intake of 40 µg/kg bw/day as set by the Joint FAO/WHO commitee. In the above study model, for the adult age group, the 95% confidence range of the median dietary exposure was calculated to be 0.037 -0.041 µg/kg bw/day with the median estimate being 0.039 µg/kg bw/day. This is in total agreement with the FSA findings. With the additional analysis available we can similarly extract estimates for youths and seniors (95% confidence range in square brackets) as 0.048 [0.046; 0.051] µg/kg bw/day, 0.035 [0.033; 0.037] µg/kg bw/day, respectively.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.