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EC number: 231-159-6 | CAS number: 7440-50-8
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
High quality chronic single-species NOEC/(L(E)C10 values are available for 17 freshwater invertebrate species. A chronic bioavailability model was developed for D. magna and validated for 6 additional speicies . The NOECs and the chronic invertebrates bioavailability model are carried forward to the risk characterisation.
High quality chronic single-species NOEC/(L(E)C10 values are available for 18 marine invertebrate species. The observed effects are related to the organic carbon contant of the test waters. The NOECS and organic carbon relationships are carried forward to the risk characterisation.
Key value for chemical safety assessment
Additional information
Freshwater invertebrate NOECS
High quality chronic NOEC/(L(E)C10 values are available for 17 species: 1 rotifer species (Brachionus calyciflorus); 3 insect species (Clistoronia magnifica; Chironomus riparius; Paratanytarsus parthenogeneticus), 6 mollusc species (Juga plicifera, Campeloma decisum; Villosa iris; Dreissenia polymorpha, Physa gyrina, Lymnaea stagnalis), 5 crustacean species (Ceriodaphnia dubia; Daphnia magna; Daphnia pulex-pulicaria; Daphnia longispina; Hyalella azteca; Gammarus pulex, Asellus aquatics).In total 166 reliable and relevant individual NOEC/(L(E)C10 values were identified. They range between 1.8 µg Cu/L (Daphnia magna reproduction) to 306 µg Cu/L (Daphnia magna reproduction) (ARCHE, 2022a).
The NOECs are used to derive “species geo-metric mean” NOEC values for each endpoint and the most sensitive endpoint for each of the 17 species of invertebrates retained as "species-mean" NOEC values. These "species mean" NOEC values range from 6.0 µg/l Cu for the snailJuga plicifera(mortality; 1 test value) to 271 µg/l Cu for the isopodAsellus aquaticus(mortality) and are carried forward for the PNEC derivation.
Large intra-species variability is observed in NOEC/L(E)C10 values. Effects data fromDaphnia magnawere used to develop a chronic invertebrate bioavailability model(ARCHE, 2022b). The capacity of the bioavailability model for predicting of copper toxicity to other invertebrate species was demonstrated from copper toxicity studies withBrachionus calyciflorus (De Schamphelaere et al., 2006), Lampilis siliquoidea (Kunz et al., 2006; Wang et al., 2009), Hyridella depressa (Markich et al., 2003),Ceriodaphnia dubia(Schwartz & Vigneault, 2006; Wang et al., 2011),Villosa iris(Wang et al., 2011)andHyalella azteca(Deaver & Rodgers, 1996; Borgman et al., 2006).
The database contains a paper demonstrating that dietary copper exposure does not affect the capacity of the biotic ligand model to predict toxicity to D. magna.
Research related to copper acclimation and deficiency, Bossuyt et al. (2004) demonstrated that after three generation of acclimation, the optimal concentration ranges (from energy reserves and number of offspring) remained constant between 1 and 35 µg Cu/L. Below 1 µg Cu/L (a concentration often used as background copper concentration in the ecotoxicity media), copper deficiency was clearly observed.
Marine invertebrate NOECs
32 high quality NOEC: L(E) C10 were retained. for 18 different individual species belonging to different taxonomic groups:6 mollusc species (Mytilus edulis; Prototheca staminea; Crassostrea gigas, Mercenaria mercenaria, Mytilus galloprovincialis, Placopecten magellanicus),1 annelid species (Neanthes arenaceodentata)3 decapod (crustacean) species (Pandalus danae; Penaeus mergulensis;Penaeus monodon),3 copepod (crustacean) species(Eurytemora affinis; Tisbe battagliai, Tisbe furcata), 1 arthropod (crustacean) species (Artemia franciscana) 1 echinoderm species (Paracentrotus lividus),3 cnidaria species(Acropora tenuis, Goniastrea aspera, Lobophytum compactum)
Reliable species- NOEC: L(E) C10 values (µg Cu/l) are calculated for the most sensitive endpoints for 18 species. The species- specific NOEC values range from 5.9 µg Cu/L for bivalveMytilus galloprovincialisto 145 µgCu/L for the crustaceaPenaeus monodonand carried forward for the marine PNEC derivation.
The observed NOEC: L(E) C10 values are influenced by the dissolved organic carbon content of the test media. A relation between the observed NOEC and organic carbon content was established forMytillus edulis. Its applicability to other invertebrate species was demonstrated forCrassostreas gigas and Paracentrotus lividus, Dendraster exentricus and Strogolocentrus purpuratus,Mytilus galloprovincialis(Arnold et al, 2008 and 2010, Hall 2010 and Brooks 2006)
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