Registration Dossier

Toxicological information

Additional toxicological data

Currently viewing:

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well-documented publication. However, this in vitro test system is considered of restricted relevance for mutagenicity assessment of TiO2.

Data source

Reference
Reference Type:
publication
Title:
Enhancement of Viral Transformation for Evaluation of the Carcinogenic or Mutagenic Potential of Inorganic Metal Salts.
Author:
Casto, B.C. et al.
Year:
1979
Bibliographic source:
Cancer Research 39, 193-198

Materials and methods

Type of study / information:
Mutagenicity
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Study only reports on isolated mechanistic investigations.
Enhancement of viral transformation in Syrian hamster embryo cells (HEC) as an in vitro test of potential carcinogens and mutagens.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

38 metal salts have been studied in the viral enhancement assay. Those chemicals which are carcinogenic or mutagenic increased the frequency of adenovirus transformation.

Applicant's summary and conclusion

Conclusions:
TiO2 belongs to the 10 compounds which were negative in enhancement of viral transformation.