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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.5 mg/m³
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
Overall assessment factor (AF):
6
Dose descriptor:
LOAEC
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

Workers - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - workers

Local lung effects observed in animals after repeated inhalational exposure were selected as the critical enpoint. The DNEL was calculated from the LOAEL using the same assessment factors as in the WHO CICAD (2009) on inorganic chromium(3 +).

Explanation of assessment factors used:

Extrapolation from LOAEC to NOAEC: An assessment factor of 1 was used because the observed effect is slight (NOAEC most likely close to LOAEC) and probably non-specific, due to overload caused by insoluble particles.

 

Interspecies extrapolation: Assessment factor 2 was used because interspecies variation is not expected to be high due to the local type of effect and because the rat is known to be a sensitive species for lung overload-related injury.

For intraspecies variation, an assessment factor of 3 was used because intraspecies variation is not expected to be high due to the local type of effect.

Based on the explanations above, the overall assessment factor applied was 6.

No other DNELs were calculated.

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.027 mg/m³
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
Overall assessment factor (AF):
20
Dose descriptor:
LOAEC
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - General Population

Also for the general population, the local lung effects observed after repeated exposure via the inhalation route were selected as the critical effect. The assessment factors used in the WHO CICAD (2009) were used for the DNEL calculations.


 


Explanation of assessment factors used:


A tolerable concentration for continuous exposure was set in the WHO CICAD (2009). The assessment factors applied in that report were also used in this CSR.


The LOAEC of 3 mg/m3 is equivalent to 0.54 mg Cr(III)/m3 for continuous exposure (3 mg x 6/24 h/day x 5/7 days/week). As for the occupational exposure, no assessment factor was used for extrapolation from the LOAEC to the NOAEC (slight effects, NOAEC most likely close to LOAEC, effects probably non-specific, due to overload caused by insoluble particles).


 


Interspecies extrapolation: Assessment factor 2 was used because interspecies variation is not expected to be high due to the local type of effect and because the rat is known to be a sensitive species for lung overload-related injury.


For interindividual differences in the general population, an assessment factor of 10 was used.


The overall assessment factor used was therefore 20.


No other DNELs were calculated.