Ammonium dihydrogenorthophosphate

Toxicity to birds

Administrative data

Endpoint:

short-term toxicity to birds

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

No data

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Remarks:

Limited information provided.

Data source

Reference

Reference Type:

publication

Title:

The response of Bobwhite quail chicks to dietary ammonium and an antibiotic-vitamin supplement when fed B1 aflatoxin.

Author:

Wilson HR; Manley JG; Harms RH; Damron BL

Year:

1978

Bibliographic source:

Poultry Science 57 (2); p. 403-7.

Materials and methods

Test guideline

Qualifier:

no guideline followed

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

CAS 7722-76-1

IUPAC Name:

CAS 7722-76-1

Constituent 2

Reference substance name:

Monoammonium phosphate (MAP)

IUPAC Name:

Monoammonium phosphate (MAP)

Constituent 3

Reference substance name:

Ammonium dihydrogenorthophosphate

EC Number:

231-764-5

EC Name:

Ammonium dihydrogenorthophosphate

Cas Number:

7722-76-1

Molecular formula:

H3N.H3O4P

IUPAC Name:

ammonium dihydrogen phosphate

Details on test material:

Monoammonium phosphate (CAS 7722-76-1), purity: not mentioned.

Dose method:

feed

Analytical monitoring:

not specified

Vehicle:

not specified

Details on preparation and analysis of diet:

Chicks were exposed to 0 or 1.46% monoammonium phosphate (= 0 or 37.5 g/kg bw) in the diet in two separate experiments.

Test organisms

Test organisms (species):

other: Bobwhite quail chicks

Details on test organisms:

Experiment 1: 32 days; Experiment 2: 28 days.
Chicks (30/treatment; 4 replicates)

Study design

Remarks:

32 or 28 days

Post exposure observation period:

No data

No. of animals per sex per dose and/or stage:

No data

Nominal and measured doses / concentrations:

No data

Examinations

Details on examinations and observations:

Mortality and feed consumption were measured. Body weight was determined at 1, 3 and 4.5 weeks in experiment 1 and at 1, 3 and 4 weeks in experiment 2.

Results and discussion

Effect levels

Effect levels 1

Duration (if not single dose):

32 d

Basis for effect:

mortality

Remarks:

6.7% and 18.3% mortality at 0 and 1.46% substance

Remarks on result:

other: bodyweight increase comparable to control

Effect levels 2

Duration (if not single dose):

28 d

Basis for effect:

mortality

Remarks:

2.5% and 5.8% mortality at 0 and 1.46% substance

Remarks on result:

other: body weight and food intake decreased

Mortality and sub-lethal effects:

Experiment 1: (32 d) Mortality was 6.7 and 18.3% at 0 and 1.46%. Body weight increase was comparable to the control group. Food intake was not reported due to excessive feed wastage.
Experiment 2: (28 d) Mortality was 2.5 and 5.8% at 0 and 1.46%. Body weight and food intake was decreased

Reported statistics and error estimates:

The increase in mortality for the treated group compared to the control group was statistically significant in experiment 1, but not significant in experiment 2.

Any other information on results incl. tables

1. The test was set up to determine the influence of monoammonium phosphate upon the presence of B1 aflatoxin in the diet. Only the groups that were given monoammonium phoshpate have been summarised here.

2. The low palatability of the feed in experiment 1 may be explained by the fact that the diet was given immediately after mixing in experiment 1 and two days later in experiment 2.