Registration Dossier
Registration Dossier
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EC number: 231-633-2 | CAS number: 7664-38-2
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Case study with limited information on individual patient who ingested phosphoric acid.
Data source
Reference
- Reference Type:
- publication
- Title:
- Liquid Caustic Ingestion. Spectrum of Injury.
- Author:
- Cello JP, Fogel RP, Boland CR
- Year:
- 1 980
- Bibliographic source:
- Arch Intern Med - Vol 140, pages 501-504
Materials and methods
- Study type:
- clinical case study
- Endpoint addressed:
- not applicable
- Principles of method if other than guideline:
- Patients who ingested liquid caustics were reviewed for location, extent, severity, and outcome of the mucosal injury.
- GLP compliance:
- no
Test material
- Reference substance name:
- Orthophosphoric acid
- EC Number:
- 231-633-2
- EC Name:
- Orthophosphoric acid
- Cas Number:
- 7664-38-2
- Molecular formula:
- H3O4P
- IUPAC Name:
- phosphoric acid
- Details on test material:
- - Name of test material (as cited in study report): phosphoric acid
Constituent 1
Method
- Subjects:
- - Number of subjects exposed: 1
- Sex: male
- Age: 42 years
- Race: no data
- Demographic information: no data
- Known diseases: no data - Route of exposure:
- oral
- Reason of exposure:
- other: suicide attempt
- Exposure assessment:
- not specified
Results and discussion
- Clinical signs:
- In the patient who ingested phosphoric acid, hematemesis and oral pharyngeal burns were observed.
Extent and severity of injury - Endoscopy and/or surgery: moderate distal esophagitis (esophagus), severe proximal gastritis (stomach), normal duodenum.
Any other information on results incl. tables
The patient was unavailable for follow-up.
Applicant's summary and conclusion
- Conclusions:
- In the patient who ingested 240 mL phosphoric acid, hematemesis and oral pharyngeal burns were observed.
Extent and severity of injury - Endoscopy and/or surgery: moderate distal esophagitis (esophagus), severe proximal gastritis (stomach), normal duodenum.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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