Registration Dossier
Registration Dossier
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EC number: 203-545-4 | CAS number: 108-05-4
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, non-guideline, animal experimental study, only brief summary available, acceptable with restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
- Principles of method if other than guideline:
- The toxicity of vinyl acetate was assessed following dermal exposure of rabbits.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Vinyl acetate
- EC Number:
- 203-545-4
- EC Name:
- Vinyl acetate
- Cas Number:
- 108-05-4
- Molecular formula:
- C4H6O2
- IUPAC Name:
- ethenyl acetate
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- Single application, no data regarding duration
- Doses:
- 4, 8, 16 mL/kg bodyweight
- No. of animals per group:
- 4
- Details on study design:
- Vinyl acetate (undiluted) was applied dermally under Vinylite covering. Animals were placed in a hood with their heads protruding into the room to prevent the inhalation of vapour.
Results and discussion
- Signs and symptoms of toxicity:
- yes
- Remarks:
- see table below
- Dermal irritation:
- yes
- Remarks:
- see table below
- Absorption in different matrices:
- Systemic toxicity and gross pathology following occluded dermal exposure demonstrates absorption.
Any other information on results incl. tables
Dose mL/kg |
Dead/dosed |
Days to death |
Weight change |
Skin condition |
Signs/Symptoms |
16.0 |
4/4 |
0,0,0,0 |
- |
Brownish |
Convulsions within 15-30 minutes. Crying. Pupils turned upwards. Dead within 25-70 minutes. |
8.0 |
2/4 |
1,2 |
-230, +44 |
Erythema, oedema, necrosis |
|
4.0 |
0/4 |
- |
-320, +24, +132, +284 |
|
|
Gross pathology – congestion of the lungs and liver; spleen and kidney mottled; liver acini prominent.
LD50 - 8.00 mL undiluted vinyl acetate/kg.
Applicant's summary and conclusion
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