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Long-term toxicity to aquatic invertebrates

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A 21 day NOELR of ≥1 mg/L has been determined for the effects of the test substance on reproduction, growth and mortality of Daphnia magna. The result was obtained in a test conducted on the sample of CTO that showed the highest toxicity in the short-term tests with D. magna. 
CTO is a UVCB substance and compositional information has been used in conjunction with validated QSARs to derive long-term No Observed Effect Concentrations (NOECs) for its constituent blocks. Calculation of PNECs for the aquatic compartment will be based on data for the constituent blocks rather than on data for the whole substance. Further testing for long-term toxicity to invertebrates will therefore not contribute to the database that is required to complete the assessment of the substance.

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