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EC number: 232-455-8 | CAS number: 8042-47-5 A highly refined petroleum mineral oil consisting of a complex combination of hydrocarbons obtained from the intensive treatment of a petroleum fraction with sulfuric acid and oleum, or by hydrogenation, or by a combination of hydrogenation and acid treatment. Additional washing and treating steps may be included in the processing operation. It consists of saturated hydrocarbons having carbon numbers predominantly in the range of C15 through C50.
Table 5.14 Summary of histological changes in rats exposed by inhalation to white oil aerosols
No. of animals in each group with a given histopathological change
Exposure Level (mg/m3)
1-2 Foamy macrophages (FM)
Thickened alveolar wall
FM in alveolar interstitium
Mild alveolar PMN infiltrate
In an inhalation toxicity study, Highly refined base oil was administered to 10 male and 10 female Sprague-Dawley rats by dynamic whole body exposure at concentrations of 0, 50, 210 and 1000 mg/m³, for 6 hours per day, 5 days/ 4 weeks.
Apart from occasional loose stool there were no treatment related clinical observations and body weights were unaffected by exposure. No treatment related effects were found in any of the hematological or clinical chemical parameters that were measured. The percent sperm with aberrant morphology, including breakage, was unaffected by exposure to any of the three base oils. There were no treatment-related observations at necropsy and, with the exception of the lungs, there were no significant changes in organ weights. The NOEL was considered to be 50 mg/m3 and LOEL was 210 mg/m3 due to the increase in lung weight.
This study received a Klimisch score of 2 and is classified as reliable with restriction because it is an acceptable well-documented study report which meets basic scientific principles.
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