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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: other routes

Currently viewing:

Administrative data

Endpoint:
repeated dose toxicity: other route
Remarks:
other: no data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
Review article with only results presented. Only Secondary Source reviewed.

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Occupational Respiratory Diseases.
Author:
Merchant JA (ed).
Year:
1986
Bibliographic source:
DHHS (NIOSH) Publication No. 86-102 : 438-444.
Reference Type:
publication
Title:
Pneumoconiosis in the tungsten carbide tool industry.
Author:
Miller CW , Davis MW, Goldman A, and Wyatt JP.
Year:
1953
Bibliographic source:
AMA Arch Ind Hyg Occ Med 8:453-465.

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
no data available on principles of method
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Tungsten
EC Number:
231-143-9
EC Name:
Tungsten
Cas Number:
7440-33-7
Molecular formula:
W
IUPAC Name:
tungsten
Constituent 2
Reference substance name:
Tungsten Metal
IUPAC Name:
Tungsten Metal

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
other: intratracheal
Vehicle:
not specified
Details on exposure:
no data
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
no data
Frequency of treatment:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data

Examinations

Statistics:
no data

Results and discussion

Results of examinations

Clinical signs:
not specified
Mortality:
not specified
Body weight and weight changes:
not specified
Food consumption and compound intake (if feeding study):
not specified
Food efficiency:
not specified
Water consumption and compound intake (if drinking water study):
not specified
Ophthalmological findings:
not specified
Haematological findings:
not specified
Clinical biochemistry findings:
not specified
Urinalysis findings:
not specified
Behaviour (functional findings):
not specified
Organ weight findings including organ / body weight ratios:
not specified
Gross pathological findings:
no effects observed
Histopathological findings: non-neoplastic:
not specified
Histopathological findings: neoplastic:
not specified
Details on results:
Rats exposed to tungsten metal showed a mild interstitial and perivascular inflammatory cell response. Increased collagen tissue was noted by eight months. Tungsten caused mild interstitial fibrosis following intratracheal injection.

Effect levels

Dose descriptor:
NOAEL
Remarks on result:
not determinable
Remarks:
no NOAEL identified

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion