Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-143-9 | CAS number: 7440-33-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998-03-25 to 2000-01-04
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Well document study following OECD Guideline 404 performed under GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Tungsten
- EC Number:
- 231-143-9
- EC Name:
- Tungsten
- Cas Number:
- 7440-33-7
- Molecular formula:
- W
- IUPAC Name:
- tungsten
- Reference substance name:
- Tungsten metal
- IUPAC Name:
- Tungsten metal
- Details on test material:
- - Name of test material (as cited in study report): Tungsten metal
- Appearance: Grey powder
- Purity: >99%
- Stored at room temperature
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan UK Ltd, Bicester, Oxon, England
- Age at study initiation: 10-11 weeks
- Weight at study initiation: 2.3-2.6 kg
- Housing: stainless steel cages with perforated floors, Building R14, Room 4
- Diet: STANRAB (P) SQC , hay ad libitum
- Water: ad libitum
- Acclimation period: 6 days
- Female
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.5- 22.0
- Humidity (%): 38-62%
- Air changes (per hr): 19/hr
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: distilled water
- Controls:
- not required
- Amount / concentration applied:
- 500 mg applied, 0.5mL distilled water added to gauze pad
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hrs: observations made at 60min, 24, 48 and 72 hours.
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 25mm x 25mm (6.25 cm^2)
- Type of wrap if used: moistened gauze covered with "Elastoplast"
REMOVAL OF TEST SUBSTANCE
-After four hours site was washed with warm water, blotted dry with absorbent paper
SCORING SYSTEM: Intact skin was evaluated for erythema and edema after 1, 24, 48 and 72 hours on a scale of 0-4 for each effect.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- A single semi-occlusive application of Tungsten Metal Powder to intact rabbit skin for four hours elicited no dermal irritation over a 72-hour period.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- A single semi-occlusive application of Tungsten Metal Powder to intact rabbit skin for four hours elicited no dermal irritation over a 72-hour period.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
